USD $100.00-150.00 / Kilogram
USD $4.50-5.00 / Liter
USD $6.00-9.00 / Gram
USD $100.00-150.00 / Kilogram
USD $6.00-9.00 / Gram
USD $100.00-150.00 / Kilogram
USD $8.20-8.80 / Kilogram
USD $15.00-50.00 / Kilogram
USD $15.00-50.00 / Kilogram
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1.noble metal catalysts (pt.pd...)
2.organic phosphine ligands (tert-butyl-phosphine.cyclohexyl-phosphine...)
3.oled intermediates (fluorene,carbazole,boric acid...)
4.customs synthesis
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2-methoxyestradiol basic information
product name: 2-methoxyestradiol
synonyms: 2,3,17beta-trihydroxy-1,3,5[10]-estratriene 2-methyl ether;3,17beta-dihydroxy-2-methoxy-1,3,5[10]-estratriene;2-methoxy-3,17beta-dihydroxyestra-1,3,5(10)-triene;2-methoxy-estra-1,3,5(10)-triene-3,17beta-diol;2-methoxyestradiol;1,3,5(10)-estratriene-2,3,17beta-triol 2-methyl ether;1,3,5[10]-estratriene-2,3,17-triol 2-methyl ether;1,3,5(10)-estratrien-2,3,17-beta-triol 2-methyl ether
cas: 362-07-2
mf: c19h26o3
mw: 302.41
einecs:
product categories: intermediates & fine chemicals;metabolites & impurities;pharmaceuticals;steroids;inhibitor;2-me2;isolabel;inhibitors
mol file: 362-07-2.mol
2-methoxyestradiol structure
2-methoxyestradiol chemical properties
melting point 188-190°c
storage temp. −20°c
solubility dmso: 10 mg/ml
form crystalline
color light yellow
cas database reference 362-07-2(cas database reference)
safety information
hazard codes t,xi,n
risk statements 23/24/25-36/37/38-48-61-60-46-45-51/53
safety statements 22-26-36/37/39-45-53-36-61
ridadr un 3077 9/pg 3
wgk germany 3
rtecs kg7537500
msds information
provider language
sigmaaldrich english
2-methoxyestradiol usage and synthesis
chemical properties off-white solid
usage a natural metabolite of 17estradiol which is devoid of estrogenic activity. inhibits cell proliferation and angiogenesis. binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a
usage a natural metabolite of 17β-estradiol which is devoid of estrogenic activity. inhibits cell proliferation and angiogenesis. binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly
usage 2-methoxyestradiol is a tubulin polymerization inhibitor and also decreases hif-1 activity.
usage 2-methoxyestradiol depolymerizes microtubules and blocks hif-1α nuclear accumulation and hif-transcriptional activity. phase 2.
usage 2-methoxy 17β-estradiol is a natural metabolite of 17β-estradiol which is devoid of estrogenic activity. inhibits cell proliferation and angiogenesis. 2-methoxy 17β-estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
biological activity apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. induces p53-induced apoptosis via two pathways: activation of p38 and nf- κ b; and activation of jnk and ap-1 leading to bcl-2 phosphorylation. also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.