USD $6.00-9.00 / Gram
USD $6.00-9.00 / Gram
USD $14.60-15.00 / Metric Ton
USD $6.00-9.00 / Gram
USD $20.00-35.00 / Metric Ton
USD $4.50-5.00 / Liter
USD $100.00-150.00 / Kilogram
USD $4.50-5.00 / Liter
USD $6.00-9.00 / Gram
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andarine basic information
biological activity in vitro in vivo characteristics
product name: andarine
synonyms: s-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-n-(4-nitro-3-trifluoromethyl-phenyl)-propionamide;n-[4-nitro-3-(trifluoromethyl)phenyl]-(2s)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methylpropanamide;ostarine;(2r)-3-(4-cyanophenoxy)-n-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide;mk-2866;andarine;propanamide,3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-n-[4-nitro-3-(trifluoromethyl)phe nyl]-,(2s)-;sarm s4
cas: 401900-40-1
mf: c19h18f3n3o6
mw: 441.36
einecs:
product categories: apis;amines;aromatics;chiral reagents;intermediates & fine chemicals;pharmaceuticals;sarms;inhibitors
mol file: 401900-40-1.mol
andarine structure
andarine chemical properties
melting point 70-74℃
density 1.47
storage temp. refrigerator
safety information
hazard codes xi
risk statements 36
safety statements 26
msds information
andarine usage and synthesis
biological activity andarine is a selective non-steroidal androgen receptor (ar) agonist with ki of 4 nm, and it is tissue selective for the metabolic organ. phase 3.
in vitro in vitro, andarine binds to androgen receptors with high affinity with ki of 4 nm. moreover, 10 nm andarine stimulated the transcription adjusted by androgen receptor, up to 93%.
in vivo in vivo, andarine has an effective metabolic activity, and stimulates the growth of the prostate, seminal vesicle, and levator ani, with ed50 is 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day respectively. this effect is dose dependent. in addition, andarine acts on fsh, which does not affect some physiological changes caused by castration, and at a dose of 0.5 mg or more per day, partially inhibiting lh production. andarine was administered to dog intravenously at 0.1, 1, 3, and 10 mg/kg doses, then the total body clearance (cl) decreased from 7.4 ml/min/kg to 3.1 ml/min/kg, the steady-state volume (vss) was 1.39 l/kg and the half-life was 229 minutes. in addition, andarine was 10 mg/kg, 1 mg/kg and 0.1 mg/kg, with oral bioavailability of 38%, 62% and 91% respectively. andarine has tissue selective pharmacological activity and is well treated with 0.5 mg/day concentration, significantly reducing prostate weight to 79.4%.
characteristics andarine is a selective non-steroidal androgen receptor (ar) agonist.
chemical properties pale yellow solid
usage it is a potent and tissue-selective androgen receptor modulator (sarm)