53984-36-4?3-CHLORO-5-HYDROXY-BENZOIC ACID CAS NO.53984-36-4

3-chloro-5-hydroxy-benzoic acid chemical properties

storage temp. room temp

solubility dmso: soluble15mg/ml (clear solution)

color white to beige

inchikey rjoliyhzzkaiet-uhfffaoysa-n

safety information

hazard codes xn

risk statements 22-37/38-41

safety statements 26-36

msds information

3-chloro-5-hydroxy-benzoic acid usage and synthesis

uses 5-chloro-m-salicylic acid was studied as a potential selective lactate receptor (gpr81) agonists with antilipolytic effects.

uses gpr81, also known as hydroxycarboxylic acid receptor 1 (hcar1), is a recently de-orphanized receptor that is activated by lactic acid (ec50 ~ 1.5 mm) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy benzoic acid (3-chloro-5-hydroxy ba) is an agonist of gpr81 (ec50 = 16 μm) that is inactive against the related gpr109a (hcar2) receptor. it is similarly effective at gpr81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy ba, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.[cayman chemical]

3-chloro-5-hydroxy-benzoic acid preparation products and raw materials