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5-fluoroorotic acid basic information |
product name: | 5-fluoroorotic acid |
synonyms: | 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci;1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicacid;5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylicaci;5-fluoroorotate;5-fluoro-oroticaci;ent-26398;fluorooroticacid;fo |
cas: | 703-95-7 |
mf: | c5h3fn2o4 |
mw: | 174.09 |
einecs: | 211-876-0 |
product categories: | aromatic halides (substituted);nucleotides and nucleosides;biochemistry;nucleobases and their analogs;nucleosides, nucleotides & related reagents;5-foa;bases & related reagents;nucleotides;pyrimidine;fluorine series |
mol file: | 703-95-7.mol |
5-fluoroorotic acid chemical properties |
mp | 278 °c (dec.)(lit.) |
storage temp. | −20°c |
solubility | nh4oh 4 m: 50 mg/ml, clear, faintly yellow |
merck | 4176 |
cas database reference | 703-95-7(cas database reference) |
safety information |
hazard codes | xn,xi |
risk statements | 22-36/37/38 |
safety statements | 26-36-36/37/39-27 |
wgk germany | 3 |
rtecs | uv7800000 |
f | 10 |
hazard note | irritant |
hazardclass | irritant |
msds information |
provider | language |
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2,6-dihydroxy-5-fluoropyrimidine-4-carboxylic acid | english |
5-fluoroorotic acid usage and synthesis |
chemical properties | white to off-white crystalline solid | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
usage |
5-foa has become a valuable tool for research in the field of molecular genetics. it has been employed in the selection of resistant strains of saccharomyces cerevisiae that possess a mutant ura3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-foa is coverted to 5-fluorouridine monophosphate (5-fump) in yeast cells, which can become incorporated into rna or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-fdump). 5-fdump is a potent inhibitor of thymidylate synthase (ts), causing the cessation of dna synthesis. more recently, 5-foa has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of plasmodium falciparum. studies indicate that ts is the primary target of 5-foa in malarial parasites. the combination of 5-foa and uracil has been effective in treating mice infected with plasmodium yoelli. 5-foa may also have potential in the treatment of human malarial infections when used in combination with other agents.
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hennan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.