China (Mainland) 
api tenofovir cas 147127-20-6 for anti-hiv pharma raw materials
tenofovir
cas: 147127-20-6
mf: c9h14n5o4p
mw: 287.21
mp 276-280°c
storage temp. store at -20°c
water solubility 13.4 mg/ml (25 oc)
chemical properties white crystalline solid
usage acyclic phosphonate nucleotide analogue. used as an anti-hiv agent
usage acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. used as an anti-hiv agent. antiviral.
purity: 99%
usage: api
package: 1kg foil bag; 25kg drum
tenofovir usage and synthesis
1. antiviral drugs, tenofovir is an acyclic nucleoside antiviral reverse transcriptase inhibitor. the active substance is tenofovir disoproxil, while tenofovir is a prodrug that is used because of its better absorption in the gut.
2. tenofovir can inhibit viral polymerase through direct competitively combine with natural deoxyribose or by insertion to terminate chain of human dna. it is the first nucleotide analogs to treat hiv-1 infection that approved by the us food and drug administration (fda).
3. tenofovir is a main medicine in aids cocktail therapy, researches has shown that it can effectively improve the monkeys` ability on prevention of immunodeficiency virus (similar to the human aids virus).
coa
|
items of analysis |
specification |
results |
|
appearance |
white powder or off-white powder |
white powder |
|
identification |
must conform to reference standard |
conforms |
|
water |
nmt3.0% |
1.53% |
|
residue on ignition |
nmt2.0% |
1.07% |
|
specific rotation |
-19.0°~-23.0° |
-22.5° |
|
sulphated ash |
≤1.5% |
0.27% |
|
single impurity |
≤1.0% |
0.29% |
|
total impurity |
≤3.0% |
1.11% |
|
assay(titrimetry) |
98.0%-102% |
98.60% |
|
9-propenyl adenine |
≤100ppm |
conforms |
|
pmpa monoester impurity |
≤1.5% |
0.35% |
|
conclusion |
qualified |
|
advantages:
hubei xinrunde chemical co., ltd is a renowned pharmaceutical manufacturer. we can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. never stop striving to offer our best service is our philosophy. we have flexible and untraceable payment terms. as a leading manufacture, our products have been exported to germany, norway, poland, finland, spain, uk, france, russia, usa, brazil, mexico, australia, japan, korea, thailand, indonesia, uruguay and many other countries.
1. quality.every batch of steroid powders have tobetested by our qc(quality control) before they are allowed to sell.
2. delivery we have stock, so we can delivery quickly at the very day when receive the payment. within 24 hours after receiving the payment lead time 4 or 7 days.
3. discreet package safelyand professionally disguised package guaranteed. for your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.
4. warm after-sale service any of your question would be solved for the first as soon as possible.