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147127-20-6

Basic Information
CAS No.: 147127-20-6
Name: Tenofovir
Molecular Structure:
Molecular Structure of 147127-20-6 (Tenofovir)
Formula: C9H14N5O4P
Molecular Weight: 287.22
Synonyms: (R)-9-[2-(phosphonomethoxy)propyl]adenine;Tenofovir disoproxil fumarate and intermediates;Phosphonic acid, (((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)-;[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid;Phosphonic acid, ((2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)-, (R)-;
EINECS: 604-571-2
Density: 1.79 g/cm3
Melting Point: 276-280 °C
Boiling Point: 616.1 °C at 760 mmHg
Flash Point: 326.4 °C
Solubility: Water solubility: 13.4 mg/mL (25 °C)
Appearance: white crystalline solid
Hazard Symbols: C
Risk Codes: R34
Safety:
Transport Information:
PSA: 146.19000
LogP: 0.53000
Synthetic route
180587-75-1

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In N,N-dimethyl-formamide at 130℃; under 7500.75 Torr; for 0.0416667h; Solvent; Pressure; Temperature; Inert atmosphere;95%
With trimethylsilyl bromide In acetonitrile at 65℃; for 1h;90%
With sulfuric acid at 90 - 110℃;83.8%
Conditions
ConditionsYield
With sodium hydroxide In water for 5h; Reflux;91.8%
160616-04-6

bis(2-propyl) (R)-9-(2-phosphonomethoxypropyl)adenine

147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 130 - 140℃; Microwave irradiation; Sealed tube;91%
With hydrogenchloride In water at 140℃; for 0.5h; Temperature; Time; Reagent/catalyst; Microwave irradiation;90%
With hydrogenchloride In water at 140℃; for 0.5h; Temperature; Reagent/catalyst; Microwave irradiation;90%
Conditions
ConditionsYield
With potassium hydroxide In water for 5h; Reflux;88.7%

tenofovir disoproxil

147127-20-6

tenofovir

Conditions
ConditionsYield
In ethyl acetate at 0 - 10℃; for 2h; Cooling with ice;85.4%
180587-75-1

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

A

magnesium para-toluenesulfonate

B

147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogen bromide at 100℃; for 15h;A n/a
B 84.6%
Conditions
ConditionsYield
With sodium hydroxide In water for 5h; Reflux;82.5%
161760-09-4

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid

14047-28-0

(R)-9-(2-hydroxypropyl)adenine

A

C9H14N5O4P

B

147127-20-6

tenofovir

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 0 - 20℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Molecular sieve;A 12%
B 82%

C12H18N5O5P

147127-20-6

tenofovir

Conditions
ConditionsYield
Stage #1: C12H18N5O5P With sodium hydroxide In water for 2h; Cooling with ice;
Stage #2: With hydrogenchloride; sodium hydroxide In water at 5℃; for 10h; pH=2.5;
81.3%

C13H20N5O5P

147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 90 - 110℃;78.1%

1-ethyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 90 - 110℃;76.8%

C13H20N5O5P

147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 90 - 110℃;76.5%
Conditions
ConditionsYield
With sodium hydroxide In water for 5h; Reflux;76.2%

C11H18N5O4P

147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 90 - 110℃;75.7%

C15H24N5O5P

147127-20-6

tenofovir

Conditions
ConditionsYield
With hydrogenchloride In water at 90 - 110℃;74%
Stage #1: C15H24N5O5P With lithium hydroxide for 2h; Cooling with ice;
Stage #2: With hydrogenchloride; sodium hydroxide In water at 5℃; for 10h; pH=2.5;
74.5%

(di-tert-butoxyphosphoryl)methyl methanesulfonate

14047-28-0

(R)-9-(2-hydroxypropyl)adenine

147127-20-6

tenofovir

Conditions
ConditionsYield
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl acetamide at 90℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: (di-tert-butoxyphosphoryl)methyl methanesulfonate In N,N-dimethyl acetamide at 90℃; for 23h; Schlenk technique; Inert atmosphere;
Stage #3: With sulfuric acid at 60℃; Reagent/catalyst; Schlenk technique; Inert atmosphere;
72%
161760-09-4

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid

14047-28-0

(R)-9-(2-hydroxypropyl)adenine

A

C10H17N5O7P2

B

147127-20-6

tenofovir

Conditions
ConditionsYield
With magnesium chloride In 1-methyl-pyrrolidin-2-one at -20 - 20℃; Inert atmosphere;A 6%
B 69%

(di-tert-butoxyphosphoryl)methyl 4-methylbenzenesulfonate

14047-28-0

(R)-9-(2-hydroxypropyl)adenine

147127-20-6

tenofovir

Conditions
ConditionsYield
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 80℃; Schlenk technique; Inert atmosphere;
Stage #2: (di-tert-butoxyphosphoryl)methyl 4-methylbenzenesulfonate In N,N-dimethyl-formamide at 80℃; for 23h; Schlenk technique; Inert atmosphere;
Stage #3: With sulfuric acid at 60℃; Schlenk technique; Inert atmosphere;
68%
161760-09-4

{[(4-methylbenzenesulfonyl)oxy]methyl}phosphonic acid

14047-28-0

(R)-9-(2-hydroxypropyl)adenine

A

C10H17N5O7P2

B

C9H14N5O4P

C

147127-20-6

tenofovir

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;A 8%
B 11%
C 64%
31618-90-3

diethyl (p-toluenesulfonyloxymethane)phosphonate

14047-28-0

(R)-9-(2-hydroxypropyl)adenine

147127-20-6

tenofovir

Conditions
ConditionsYield
With bis(isopropoxy) magnesium In N,N-dimethyl-formamide at 45 - 65℃; for 11h; Autoclave; Inert atmosphere; Large scale;59.2%
Stage #1: diethyl (p-toluenesulfonyloxymethane)phosphonate; (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In 1-methyl-pyrrolidin-2-one; toluene at 25 - 75℃; for 6h;
Stage #2: With water; acetic acid In 1-methyl-pyrrolidin-2-one; water; acetic acid; toluene for 1h;
Stage #3: With hydrogen bromide In 1-methyl-pyrrolidin-2-one; water; toluene at 90 - 95℃;
Stage #1: (R)-9-(2-hydroxypropyl)adenine With magnesium 2-methylpropan-2-olate In N,N-dimethyl-formamide at 20 - 35℃; for 0.5h;
Stage #2: diethyl (p-toluenesulfonyloxymethane)phosphonate In N,N-dimethyl-formamide at 75 - 80℃; for 2h;
Stage #3: With hydrogenchloride In N,N-dimethyl-formamide at 0 - 95℃; for 9h; Temperature; Reagent/catalyst;
82 g
With trimethylsilyl bromide; water; sodium hydroxide In dichloromethane at 0 - 5℃; for 3h; pH=2.5 - 3;
Stage #1: diethyl (p-toluenesulfonyloxymethane)phosphonate; (R)-9-(2-hydroxypropyl)adenine With alumina-supported potassium hydroxide In N,N-dimethyl-formamide at 40 - 130℃; for 18h;
Stage #2: With water at 100 - 105℃; for 18h; Reagent/catalyst; Temperature; Solvent;

(R)-(((1-chloropropan-2-yl)oxy)methyl)phosphonic acid bis(diethylamide)

73-24-5

7H-purin-6-ylamine

147127-20-6

tenofovir

Conditions
ConditionsYield
Stage #1: (R)-(((1-chloropropan-2-yl)oxy)methyl)phosphonic acid bis(diethylamide); 7H-purin-6-ylamine With potassium phosphate In N,N-dimethyl acetamide at 120℃; for 24h; Inert atmosphere;
Stage #2: With hydrogenchloride In water at 80℃; for 0.75h; Inert atmosphere;
41%
180587-75-1

(R)-diethyl (((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

A

147127-20-6

tenofovir

B

(R)-9-(2-phosphonomethoxypropyl)hypoxanthine

Conditions
ConditionsYield
With hydrogenchloride

C15H30N5O4PSi2

147127-20-6

tenofovir

Conditions
ConditionsYield
With water30.3 g
With water In acetonitrile
Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaOH / dimethylformamide / 20 h / 140 °C
2: LiOt-Bu / dimethylformamide; tetrahydrofuran / 1 h / 30 - 35 °C
3: 1.) bromotrimethylsilane, 2.) NaOH / 1.) acetonitrile, reflux, 2.) H2O, pH 3
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / N,N-dimethyl-formamide / 120 °C
2: magnesium 2-methylpropan-2-olate / 1-methyl-pyrrolidin-2-one / 70 - 74 °C
3: chloro-trimethyl-silane; sodium bromide / 1-methyl-pyrrolidin-2-one / 0 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 25 - 30 °C
1.2: 25 - 120 °C
1.3: 0.17 h / 55 - 70 °C
2.1: magnesium 2-methylpropan-2-olate / dimethyl sulfoxide / 70 °C
3.1: sodium bromide; chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one / 16 h / 0 - 75 °C
View Scheme
14047-28-0

(R)-9-(2-hydroxypropyl)adenine

147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiOt-Bu / dimethylformamide; tetrahydrofuran / 1 h / 30 - 35 °C
2: 1.) bromotrimethylsilane, 2.) NaOH / 1.) acetonitrile, reflux, 2.) H2O, pH 3
View Scheme
Multi-step reaction with 2 steps
1: 44 percent / NaH / dimethylformamide / 0 - 20 °C
2: 1.) TMSBr, 2.) H2O / 1.) MeCN, RT, 2.) acetone, 4 deg C
View Scheme
Multi-step reaction with 4 steps
1: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h
2: sodium hydride / dimethylformamide / 48 h / Ambient temperature
3: sodium methoxide / dimethylformamide / Ambient temperature
4: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature
View Scheme
17435-30-2

(R)-1-(5-Amino-6-chloro-pyrimidin-4-ylamino)-propan-2-ol

147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 86 percent / conc. HCl / Ambient temperature
2: 91 percent / NH3 / 65 °C
3: 44 percent / NaH / dimethylformamide / 0 - 20 °C
4: 1.) TMSBr, 2.) H2O / 1.) MeCN, RT, 2.) acetone, 4 deg C
View Scheme
180587-74-0

(R)-1-(6-chloro-9H-purin-9-yl) propan-2-ol

147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / NH3 / 65 °C
2: 44 percent / NaH / dimethylformamide / 0 - 20 °C
3: 1.) TMSBr, 2.) H2O / 1.) MeCN, RT, 2.) acetone, 4 deg C
View Scheme
Multi-step reaction with 2 steps
1: ammonium hydroxide / 1,4-dioxane / 100 - 110 °C / Sealed tube; Large scale
2: bis(isopropoxy) magnesium / N,N-dimethyl-formamide / 11 h / 45 - 65 °C / Autoclave; Inert atmosphere; Large scale
View Scheme
160616-02-4

(R)-9-<2-(2-tetrahydropyranyloxy)propyl>adenine

147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 85 percent / sulfuric acid / Ambient temperature
2: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h
3: sodium hydride / dimethylformamide / 48 h / Ambient temperature
4: sodium methoxide / dimethylformamide / Ambient temperature
5: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature
View Scheme
160616-03-5

(R)-9-(2-hydroxypropyl)-N6-benzoyladenine

147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / dimethylformamide / 48 h / Ambient temperature
2: sodium methoxide / dimethylformamide / Ambient temperature
3: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature
View Scheme
627510-49-0

[(R)-2-(6-Benzoylamino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropyl ester

147127-20-6

tenofovir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium methoxide / dimethylformamide / Ambient temperature
2: 47 percent / bromotrimethylsilane / acetonitrile / Ambient temperature
View Scheme
68-12-2, 33513-42-7

N,N-dimethyl-formamide

147127-20-6

tenofovir

C12H17Cl2N6O2P

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane at 20℃; for 3h; Inert atmosphere;100%
With oxalyl dichloride In dichloromethane at 20℃; for 3h; Inert atmosphere;100%
147127-20-6

tenofovir

C9H13N5O4P(1-)*K(1+)

Conditions
ConditionsYield
With potassium hydrogencarbonate In water at 40℃;99.5%
101-02-0

triphenyl phosphite

147127-20-6

tenofovir

379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With pyridine at 50 - 115℃; for 6h;98%
With dmap; triethylamine at 100 - 110℃; Reagent/catalyst; Temperature;91%
With dmap; triethylamine In N,N-dimethyl acetamide at 105 - 110℃; for 20h; Reagent/catalyst; Temperature;89.03%
147127-20-6

tenofovir

C9H13N5O4P(1-)*Cs(1+)

Conditions
ConditionsYield
With caesium carbonate In water; acetone at 30℃;97.6%
147127-20-6

tenofovir

C9H13N5O4P(1-)*Li(1+)

Conditions
ConditionsYield
With lithium hydroxide In acetone at 30℃;96.5%
4712-55-4

diphenyl hydrogen phosphite

147127-20-6

tenofovir

108-95-2

phenol

379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With pyridine at 100 - 110℃; for 2h;95%
147127-20-6

tenofovir

108-95-2

phenol

379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With pyridine; dicyclohexyl-carbodiimide at 70℃; for 4h;93.63%
Stage #1: tenofovir; phenol In acetic acid butyl ester at 20℃; for 1h;
Stage #2: With dmap; triethylamine; dicyclohexyl-carbodiimide In acetic acid butyl ester at 90℃; for 24h;
85%
With triphenyl phosphite; dmap; triethylamine In toluene; acetonitrile at 100℃; for 28h; Solvent; Temperature;83%
147127-20-6

tenofovir

C18H26N10O7P2

Conditions
ConditionsYield
With pyridine; dmap; phosphoric acid triphenyl ester In toluene; acetonitrile for 24h; Solvent; Temperature; Reagent/catalyst; Reflux;92.9%
With pyridine; triethylamine; dicyclohexyl-carbodiimide at 70℃; for 3h; Temperature; Reagent/catalyst;88.7%
With triethylamine; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 90 - 100℃; for 22h; Solvent; Reagent/catalyst; Temperature;45.5%
115-86-6

phosphoric acid triphenyl ester

147127-20-6

tenofovir

379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With dmap; triethylamine In 5,5-dimethyl-1,3-cyclohexadiene at 100 - 110℃; for 12h; Temperature; Solvent;91.97%
4712-55-4

diphenyl hydrogen phosphite

147127-20-6

tenofovir

379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With pyridine at 110 - 120℃; for 4h;91.7%
35180-01-9

chloromethyl isopropyl carbonate

147127-20-6

tenofovir

tenofovir disoproxil

Conditions
ConditionsYield
With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 50℃; Temperature;91.5%
With triethylamine; N-butylpyridinium tetrafluoroborate at 40℃; for 1.5h; Reagent/catalyst; Temperature;90.6%
Stage #1: tenofovir With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one at 50℃; for 0.5h;
Stage #2: chloromethyl isopropyl carbonate In 1-methyl-pyrrolidin-2-one at 60℃; for 4h; Reagent/catalyst; Solvent;
87.6%
147127-20-6

tenofovir

C9H13N5O4P(1-)*Na(1+)

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 30℃; Reagent/catalyst; Solvent; Temperature;90.6%
35180-01-9

chloromethyl isopropyl carbonate

110-17-8

(2E)-but-2-enedioic acid

147127-20-6

tenofovir

202138-50-9

tenofovir disoproxyl fumarate

Conditions
ConditionsYield
Stage #1: tenofovir With triethylamine In 1-methyl-pyrrolidin-2-one at 63℃; for 0.5h;
Stage #2: chloromethyl isopropyl carbonate In 1-methyl-pyrrolidin-2-one at 63℃; for 4h;
Stage #3: (2E)-but-2-enedioic acid In isopropyl alcohol at 50℃; for 0.5h; Concentration;
90%
Stage #1: chloromethyl isopropyl carbonate; tenofovir With tetrabutylammomium bromide; triethylamine at 50℃; for 3h; Inert atmosphere;
Stage #2: (2E)-but-2-enedioic acid In isopropyl alcohol Reagent/catalyst; Temperature; Reflux;
78.8%
Stage #1: chloromethyl isopropyl carbonate; tenofovir With tetrabutylammomium bromide; triethylamine In 1-methyl-pyrrolidin-2-one; toluene at 45 - 55℃; for 5h;
Stage #2: (2E)-but-2-enedioic acid In isopropyl alcohol at 50 - 55℃; for 2h;
63.6%
50-00-0

formaldehyd

147127-20-6

tenofovir

C19H28N10O8P2

Conditions
ConditionsYield
Stage #1: formaldehyd With hydrogenchloride In N,N-dimethyl-formamide at 35 - 40℃; for 1h;
Stage #2: tenofovir at 10 - 15℃; for 48h;
89.5%
66003-76-7

Diphenyliodonium triflate

147127-20-6

tenofovir

379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With triethylamine In toluene Inert atmosphere; Heating;88.3%

diphenyliodonium tetrafluoroborate

147127-20-6

tenofovir

379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With dmap In acetic acid butyl ester Inert atmosphere; Heating;87%
1483-73-4

diphenyliodonium bromide

147127-20-6

tenofovir

379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With toluene In acetic acid butyl ester at 80℃; Inert atmosphere;86.3%
147127-20-6

tenofovir

108-95-2

phenol

9-[(R)-2-[[(S)-[bis(phenoxy)phosphinyl]]methoxy]propyl]adenine

Conditions
ConditionsYield
Stage #1: tenofovir With thionyl chloride In acetonitrile at 70℃; for 2h; Inert atmosphere; Large scale;
Stage #2: phenol In acetonitrile at 80℃; for 13h; Large scale;
85%
58109-40-3

diphenyliodonium hexafluorophosphate

147127-20-6

tenofovir

379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile Inert atmosphere; Heating;84.2%

diphenyliodonium nitrate

147127-20-6

tenofovir

379270-35-6

((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoric acid monophenyl ester

Conditions
ConditionsYield
With potassium tert-butylate In dichloromethane Inert atmosphere; Heating;80.1%
39613-92-8, 62062-56-0, 62062-65-1

alanine isopropyl ester hydrochloride

147127-20-6

tenofovir

P-{[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}-N-[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]phosphonamidic acid

Conditions
ConditionsYield
Stage #1: tenofovir With thionyl chloride In toluene at 80 - 90℃; for 20h;
Stage #2: alanine isopropyl ester hydrochloride With sodium sulfate In dichloromethane; toluene at -15℃; for 4h; Inert atmosphere;
80%
With 1,2-dichloro-ethane; triethylamine In water at 20 - 40℃; for 16h; pH=7.2 - 7.6;
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In water at 80 - 90℃; for 48h;
Downstream Products
202138-50-9
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  • Tenofovir 99% Manufactuered in China best quality

  • Casno:

    147127-20-6

    Tenofovir 99% Manufactuered in China best quality

    Min.Order: 100 Gram

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    Product Name: Tenofovir Synonyms: (R)-(1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methylphosphonic acid;Tenofovir (PMPA);Tenofovir(Viread);[[(1R)-2(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]ph;Viread;1-(6-AMinopurin-9-yl)propan-2-yloxyMethylphos

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  • Tenofovir(PMPA)/147127-20-6 / with DMF

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    147127-20-6

    Tenofovir(PMPA)/147127-20-6 / with DMF

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    Tenofovir(PMPA)/147127-20-6 / with DMF (R)-9-[2-(phosphonomethoxy)propyl]adenine;Tenofovir disoproxil fumarate and intermediates;Phosphonic acid, (((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)-;[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxy

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    147127-20-6

    Tenofovir Intermediate - PMPA

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    147127-20-6

    Tenofovir

    Min.Order: 100 Metric Ton

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    Appearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/A

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  • Tenofovir

  • Casno:

    147127-20-6

    Tenofovir

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

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Chemistry

Empirical Formula: C9H14N5O4P
Molecular Weight: 287.2123 g/mol
Index of Refraction: 1.739
Density: 1.79 g/cm3
Flash Point: 326.4 °C
Melting point: 276-280 °C
Enthalpy of Vaporization: 96.07 kJ/mol
Boiling Point: 616.1 °C at 760 mmHg
Vapour Pressure: 4.92E-16 mmHg at 25 °C
Water solubility: 13.4 mg/mL (25 °C)
Appearance: White crystalline solid
Structure of Tenofovir (CAS NO.147127-20-6):
                          
IUPAC Name: [(2R)-1-(6-Aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
Product Category of Tenofovir (CAS NO.147127-20-6): Purine;Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates & Fine Chemicals

Uses

 Tenofovir (CAS NO.147127-20-6) is acyclic phosphonate nucleotide analogue, and has been used as an anti-HIV agent.

Specification

 Tenofovir , its cas register number is 147127-20-6. It also can be called 1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid ; and PMPA prodrug .

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