atorvastatin calcium 134523-03-8
atorvastatin calcium basic information |
product name: | atorvastatin calcium |
synonyms: | lipitor;atorvastatin calcium salt;atorvastatin calcium;atorvastatin ca;[r-(r*, r*)]-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylaminocarbonyl)-1h-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid calcium salt;1h-pyrrole-1-heptanoicacid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methy;calciumsalt(2:1),(r-(r*,r*))-lethyl)-3-phenyl-4-((phenylamino)carbonyl);ci-981 |
cas: | 134523-03-8 |
mf: | c66h68caf2n4o10 |
mw: | 1155.36 |
einecs: | 200-659-6 |
product categories: | active pharmaceutical ingredients;inhibitors;intermediates & fine chemicals;pharmaceuticals;atorvastatin;aromatics;chiral reagents;pfizer compounds;pharmaceutical intermediates;isotope;lipitor;cardiovascular apis;antilipemic agent;api |
mol file: | 134523-03-8.mol |
atorvastatin calcium 134523-03-8
atorvastatin calcium chemical properties |
mp | 176-178°c |
storage temp. | store at +4°c |
cas database reference | 134523-03-8(cas database reference) |
safety information |
hazard codes | xn,t,f |
risk statements | 20/21/22-36/37/38-39/23/24/25-23/24/25-11 |
safety statements | 26-36-45-36/37-16-7 |
atorvastatin calcium usage and synthesis |
chemical properties | white crystalline powder |
usage | a selective, competitive hmg-coa reductase inhibitor. the only drug in its class specfically indicated for lowering both elevated ldl-cholesterol and triglycerides in patients with hypercholesterolemia |
usage | a selective, competitive hmg-coa reductase inhibitor. atorvastatin is the only drug in its class specfically indicated for lowering both elevated ldl-cholesterol and triglycerides in patients with hypercholesterolemia. |
usage | antihyperlipidemic, hmgcoa reductase inhibitor |
usage | dmso and etoh soluble |
usage | the primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease. |
biological activity | potent hmg-coa reductase inhibitor (ic 50 = 8 nm). reduces circulating ldl-c by inhibiting cholesterol biosynthesis and inducing expression of ldl receptors. inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model. |