China (Mainland) 
high quality hydrocortisone 50-23-7
appearance: white fine powder
specification: 99%
mf: c21h30o5
mw:362.46
high quality hydrocortisone 50-23-7
appearance: white fine powder
specification: 99%
mf: c21h30o5
mw:362.46
standard: bp, usp ,ep
packing: 25kg/drum
function
hydrocortisone is a natural corticosteroid produced by the adrenal glands located adjacent to the kidneys.
corticosteroids have potent antiinflammatory propeties,
and are used in a wide variety of inflammatory conditions such as arthritis, colitis, asthma, bronchitis, certain skin rashes,
and allergic or inflammatory conditions
coa
|
items |
specification ep6/usp32 |
results |
|
characters(ph.eur.) |
a white or almost white,crystalline powder |
white crystalline powder |
|
solubility(ph.eur.) |
practically insoluble in water,sparingly soluble in acetone and in alcohol,slightly in methylene chloride |
complies |
|
identification |
||
|
a.ir-spectrum(ph.eur) |
meets the requirement |
complies |
|
b.tlc(ph.eur) |
meets the requirement |
complies |
|
a.ir-spectrum(usp) |
meets the requirement |
complies |
|
b.uv absorption(usp) |
meets the requirement |
complies |
|
specific optical rotation |
||
|
(ph.eur) |
between+150°and +156° |
+152.6° |
|
(usp) |
between+150°and +156° |
+152.6° |
|
loss on drying |
||
|
(ph.eur) |
not more than 1.0% |
0.06% |
|
(usp) |
not more than 1.0% |
0.09% |
|
residue on ignition(usp) |
negligible,from 100mg |
complies |
|
related substances(ph.eur) |
||
|
any individual impurity |
not more than 0.5% |
0.23% |
|
sum of impurities |
not more than 1.5% |
1.00% |
|
chromatographic purity(usp) |
||
|
any individual impurity |
not more than 0.5% |
0.20% |
|
sum of impurities |
not more than 2.0% |
1.06% |
|
assay |
||
|
uv absorption(ph.eur.) |
between 97.0% and 103.0% |
100.4% |
|
hplc(usp) |
between 97.0% and 102.0% |
99.9% |
|
residual solvent(in-house) |
||
|
methanol |
not more than 500ppm |
not detect out |
|
ethanol |
not more than 2000ppm |
243ppm |
|
methylene chloride |
not more than 600ppm |
not detect out |
|
items |
specification |
results |
|
chloroform |
not more than 60ppm |
not detect out |
|
particle size(in-house) |
90% not more than 15 microns |
complies |
|
conclusion:the product conforms to ph.eur.6/usp34 |
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