Welcome to LookChem.com Sign In|Join Free
  • or
Home > Pharmaceutical > 59 > 

59-05-2

Basic Information
CAS No.: 59-05-2
Name: Methotrexate
Article Data: 25
Molecular Structure:
Molecular Structure of 59-05-2 (Methotrexate)
Formula: C20H22N8O5
Molecular Weight: 454.445
Synonyms: Glutamicacid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-(8CI);(+)-Amethopterin;Amethopterin;Amethopterine;Antifolan;CL 14377;EMT 25299;Emtexate;Emthexate PF;L-Amethopterin;L-Methotrexate;Ledertrexate;Metatrexan;Mexate;N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(+)-glutamicacid;NSC 740;R 9985;Rheumatrex;Trexall;
EINECS: 200-413-8
Density: 1.536 g/cm3
Melting Point: 195 °C
Boiling Point: 561.26°C (rough estimate)
Flash Point: 11℃
Solubility: insoluble in water
Appearance: yellow crystalline powder
Hazard Symbols: ToxicT
Risk Codes: 61-25-36/38-46
Safety: 53-26-36/37-45-36/37/39
Transport Information: UN 2811 6.1/PG 3
PSA: 210.54000
LogP: 1.82170
  • Display:default sort

    New supplier

  • competitive price for Methotrexate USP

  • Casno:

    59-05-2

    competitive price for Methotrexate USP

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Product: Methotrexate[CAS:59-05-2] Synonyms (+)-Amethopterin; (+)-4-Amino-10-methylfolic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid Name Methotrexate Sy

    HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketi

  •  Hangzhou Think Chemical Co. Ltd

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-571-89986307/81956191/81956084/81956192

    Address:Room 501-502, Tower E, Yuanjian Building, Yuanyang International Center, Hangzhou-310011, China

       Inquiry Now

  • Methotrexate CAS 59-05-2

  • Casno:

    59-05-2

    Methotrexate CAS 59-05-2

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-3.0

    Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. Methotrexate originated in the 1940s when Dr. Sidney Fa

    Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of

  •  Hebei yanxi chemical co.,LTD.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 17531153977

    Address:Zhang zhe, guangzong county, xingtai city, hebei province

       Inquiry Now

  • Factory Price 99% Methotrexate Powder Methotrexate Cas 59-05-2

  • Casno:

    59-05-2

    Factory Price 99% Methotrexate Powder Methotrexate Cas 59-05-2

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 170.0-180.0

    Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, Am

    Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in carbomer, Dibenzylamine,meglumine,lead acetate and other chemical raw materials and chemical reagents research

  •  Hebei Mojin Biotechnology Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:13231137666

    Address:room 1401,A building,Enjoy city,shijiazhuang city,hebei province,China

       Inquiry Now

  • L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-

  • Casno:

    59-05-2

    L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-

    Min.Order: 10 Gram

    FOB Price:  USD $ 100.0-100.0

    Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

    Hangyu Biotech is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and O

  •  Zibo Hangyu Biotechnology Development Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-15965530500

    Address:Room1701, Tianxing Building,Licheng district, jinan, Shandong, China

       Inquiry Now

  • Methotrexate Manufacturer/High quality/Best price/In stock

  • Casno:

    59-05-2

    Methotrexate Manufacturer/High quality/Best price/In stock

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 3.0-3.0

    As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

    Dayang Chem (Hangzhou) Co.,Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredi

  •  Dayang Chem (Hangzhou) Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-88938639

    Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China

       Inquiry Now

  • Methotrexate  59-05-2

  • Casno:

    59-05-2

    Methotrexate 59-05-2

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    Hubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good ser

    Wuhan Vanz Pharm Inc. is a manufacturer&trading company.

  •  Hubei Vanz Pharm Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-27-84492310

    Address:FANHU INDUSTRY PARK

       Inquiry Now

  • Methotrexate tablets 2.5mg

  • Casno:

    59-05-2

    Methotrexate tablets 2.5mg

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

    Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd (JL Pharm) is established in 2012 at the beautiful West Lake – Hangzhou city, China. The company's main business includes R&D, Produ

  •  Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-571-85829053

    Address:Rm A606, Fuyi Center, jianqiao street, Jianggan Area

       Inquiry Now

  • Methotrexate Cas 59-05-2 with high quality best purity

  • Casno:

    59-05-2

    Methotrexate Cas 59-05-2 with high quality best purity

    Min.Order: 250 Gram

    FOB Price:  USD $ 800.0-800.0

    Unique advantages for Methotrexate Cas 59-05-2 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:?20°C Package:1kg/bag, 25kg/drum or as you required Application:

    Wuhan Fortuna Chemical Co., Ltd, located in the predominant Wu Han City where is a traffic hinge of China, is a big integrative chemical enterprise being engaged in producing and

  •  Wuhan Fortuna Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-27-59207852

    Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China

       Inquiry Now

  • Methotrexate

  • Casno:

    59-05-2

    Methotrexate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 2.0-3.0

    Methotrexate Character Orange yellow crystalline powder; the product hardly dissolves in water, ethanol, chloroform or ether, and it easily dissolves in dilute alkali, and it can dissolve in dilute hydrochloric acid. Application: Used as anti

    Founded in 2008, East Chemsources Limited is a professional manufacturer of supplier in food and beverage, pharmaceuticals, cosmetics and other industries. pharmaceutical field in

  •  EAST CHEMSOURCES LIMITED

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-532-81906761

    Address:No.1581-12,Jinshui Road, Licang, Qingdao,China

       Inquiry Now

  • Factory Supply Methotrexate

  • Casno:

    59-05-2

    Factory Supply Methotrexate

    Min.Order: 1

    FOB Price:  USD $ 0.0-0.0

    The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

    Ality Chemical, established in 2007, is a comprehensive Chemical Production&Supply Group with Patent Technology as its core. Ality Chemical operates sales branches in Shanghai, Xia

  •  Ality Chemical Corporation

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:0513-87616220

    Address:Fine chemical industry park, Nantong,Jiangsu

       Inquiry Now

  • Factory Price API 99% Methotrexate 59-05-2 GMP Manufacturer

  • Casno:

    59-05-2

    Factory Price API 99% Methotrexate 59-05-2 GMP Manufacturer

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.1-0.1

    1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

    Xi'an Xszo Chem Co. Ltd is a wholly-owned subsidiary of the SZO Chem Group. SZO Group is composed of Xi'an Xszo Chem Co. Ltd & Shaanxi SZO Tech Co., Ltd. SZO industry Group have mo

  •  Xi'an Xszo Chem Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-029-88698540

    Address:No.16,Jingqin Rd. JingWei Industrial park,Shaanxi,China,710200

       Inquiry Now

  • lower price High quality Methotrexate

  • Casno:

    59-05-2

    lower price High quality Methotrexate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-1.0

    Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

    Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech bio chemical products enterprises. The company's

  •  Shanghai Seasonsgreen Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86 156 1855 4368

    Address:No.12, Lane 356, Chengnan Road, Chuansha Town, Shanghai

       Inquiry Now

  • High Quality 99% API Methotrexate powder CAS:59-05-2

  • Casno:

    59-05-2

    High Quality 99% API Methotrexate powder CAS:59-05-2

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    High Quality 99% API Methotrexate powder from Wuxi TAA Chemical Industry Co.,Ltd. 1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or ex

    Wuxi TAA Chemical Industry Co.,Ltd., established in 2010, is a key chemical manufacturer and supplier in China. In 2010, three young chemists from a local large state-owned chemi

  •  Wuxi TAA Chemical Industry Co.,LTD.

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:18168326835

    Address:2202 Scientific Research Business Center, Lihu Road, Wuxi 214128 China

       Inquiry Now

  • Factory Supply Methotrexate powder CAS 59-05-2

  • Casno:

    59-05-2

    Factory Supply Methotrexate powder CAS 59-05-2

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 500.0-500.0

    Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

    Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of ph

  •  Sinoway Industrial Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-592-583819

    Address:16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China

       Inquiry Now

  • Methotrexate 99% purity assay, ready stock

  • Casno:

    59-05-2

    Methotrexate 99% purity assay, ready stock

    Min.Order: 25 Kilogram

    FOB Price:  USD $ 1.0-2.0

    Name:Methotrexate CAS:59-05-2 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Pro

    Hubei DiBo chemical co., LTD Hubei DiBo Chemical Co., Ltd. was founded in 2009, is located in Hubei Province on both sides of the Yangtze River, one of the ancient cities of Chines

  •  Hubei DiBo chemical co., LTD

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86 15871366807

    Address:No. 782 of wuchang district of wuhan city, hubei province

       Inquiry Now

  • TIANFU-CHEM - Methotrexate

  • Casno:

    59-05-2

    TIANFU-CHEM - Methotrexate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1000.0-1000.0

    Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

    Our company engages in Electronic chemicals such as OLED,Photoresist chemical,Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

       Inquiry Now

  • 59-05-2 Methotrexate

  • Casno:

    59-05-2

    59-05-2 Methotrexate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 15.0-50.0

    Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

    Our company specializes in processing and selling chemical raw materials, chemical th Asia, Europe, America, Africa and other more than 20 countries and regions. ? Companies adheri

  •  Hebei Nengqian Chemical Import and Export Co., LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 13910575315

    Address:hebei

       Inquiry Now

  • Factory direct supply CAS 59-05-2 with best quality

  • Casno:

    59-05-2

    Factory direct supply CAS 59-05-2 with best quality

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 139.0-210.0

    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is (Wen Xi Pharma), including three subs

  •  Zhuozhou Wenxi import and Export Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

       Inquiry Now

  • Methotrexate Manufacture With High Purty Methotrexate USP

  • Casno:

    59-05-2

    Methotrexate Manufacture With High Purty Methotrexate USP

    Min.Order: 25 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Appearance:Yellow crystalline powder Storage:Room temperature Package:25kg/drum Application:Anti-foliumzuur antitumor API Transportation:Express/Sea/Air Port:Any port in china

    Founded in 2005, Sartort, located in Hangzhou, is a leading company engaging in chemistry, pharmaceutical and advanced materials. At present, Sartort has such controlled subsidi

  •  Hangzhou Sartort Biopharma Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-87039693

    Address:No. 57, Tech Park Road, Hangzhou, Zhejiang, China

       Inquiry Now

  • L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- 59-05-2

  • Casno:

    59-05-2

    L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- 59-05-2

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

    Shanghai Upbio Tech Co.,Ltd (Former Onchem (China)Co.,Ltd) is a comprehensive manufacturer and an international distribution of chemicals throughout the world, The predecessor of

  •  Shanghai Upbio Tech Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-21-52196435

    Address:No.2 Floor,No.979 Yunhan Rd,Nicheng,Pudong New Area,Shanghai,China

       Inquiry Now

  • GMP Factory Supply Methotrexate

  • Casno:

    59-05-2

    GMP Factory Supply Methotrexate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-1.0

    Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

    Hubei Hanways Pharmchem Co.,Limited is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. Now we

  •  HANWAYS CHEMPHARM CO.,LIMITED

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-18502787239(whatsapp)

    Address:18-1-802, Green Garden, Jianghan District, Wuhan 430023, China

       Inquiry Now

  • Supply Methotrexate CAS 59-05-2 for Scientific Research use only

  • Casno:

    59-05-2

    Supply Methotrexate CAS 59-05-2 for Scientific Research use only

    Min.Order: 1 Gram

    FOB Price:  USD $ 1.0-5.0

    About Product Details Items Specifications Test Results Appearance White to white crystalline powde

    Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into p

  •  Leader Biochemical Group

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-029-68895030

    Address:Aerospace Economic & Technical Development Zone, Chang'an District,Xi'an,China

       Inquiry Now

  • Methotrexate/CAS:59-05-2

  • Casno:

    59-05-2

    Methotrexate/CAS:59-05-2

    Min.Order: 100 Milligram

    FOB Price:  USD $ 45.0-45.0

    Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

    Baoji Guokang Healthchem co.,ltd located in Baoji High-tech Zone,is epitomizing international,cooperative and honest.We are a young company full of action and energy,and our profes

  •  Baoji Guokang Healthchem co.,ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-917-3909592

    Address:China

       Inquiry Now

  • High quality Methotrexate CAS 59-05-2

  • Casno:

    59-05-2

    High quality Methotrexate CAS 59-05-2

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    Beluga chemical professional supply High quality Methotrexate CAS 59-05-2 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and e

    Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speciali

  •  Qingdao Beluga Import and Export Co., LTD

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+8613854236000

    Address:qingdao

       Inquiry Now

  • Methotrexate

  • Casno:

    59-05-2

    MSDS/COA Download

    Methotrexate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 30.0-50.0

    1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

    Hebei Quanhe Biotechnology Co. LTD. is an enterprise specializing in the research and development, production and trade of pharmaceutical intermediates, apis and chemical raw mater

  •  Hebei Quanhe Biotechnology Co. LTD

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-0319-5919066

    Address:Haida Business Center, Xiangdu District

       Inquiry Now

  • Factory supply  Methotrexate

  • Casno:

    59-05-2

    Factory supply Methotrexate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Methotrexate CAS: 59-05-2 Specification Appearance & Physical State yellow crystalline powder Density 1.536 g/cm3 Melting Point 195ºC Water Solubility Insoluble. Stability Stabl

    Lonwin industry group limited.is a comprehensive chemical enterprise which mainly integrates development, production, marketing ,import and export business. The company is located

  •  Lonwin Chemical Group Limited

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:Tel: 86-21-59858395

    Address:No#966,Huaxu Road,Shanghai 201702,P.R.China

       Inquiry Now

  • Methotrexate

  • Casno:

    59-05-2

    Methotrexate

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

    AFINE CHEMICALS LIMITED is specialized in the fine chemicals and pharmaceuticals and we have enjoyed great popularity in world markets. Since 2005, we have been rapidly growing to

  •  Afine Chemicals Limited

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-85134551

    Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China

       Inquiry Now

  • 99% Methotrexate CAS 59-05-2 with Best Price

  • Casno:

    59-05-2

    99% Methotrexate CAS 59-05-2 with Best Price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 3.0-5.0

    Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

    Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exp

  •  Hubei Yuanmeng Biological Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-027-68897569

    Address:Hongshan District

       Inquiry Now

  • Amethopterin Methotrexate 59-05-2

  • Casno:

    59-05-2

    Amethopterin Methotrexate 59-05-2

    Min.Order: 20 Gram

    FOB Price:  USD $ 0.0-0.0

    Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

    Taizhou Crene Biotechnology Co., Ltd.is a leading supplier of active pharmaceutical ingredients (APIs), with GLP labs and GMP manufacturing facilities engaging in organic synthesis

  •  Taizhou Crene Biotechnology co.ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-576-88813233 88205808

    Address:Economic Developed Zone of Taizhou Zhejiang China

       Inquiry Now

  • methotrexate

  • Casno:

    59-05-2

    methotrexate

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0

    Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

    Hangzhou Keying Chem Co., Ltd. Is a comprehensive enterprise, dedicated to the development, production and marketing of chemicals. As a technology innovative and service profession

  •  Hangzhou Keyingchem Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-85378921

    Address:Jintong international Building, No.113,Huayuangang Street, Gong shu District, Hangzhou,Zhejiang, China.

       Inquiry Now

  • L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-

  • Casno:

    59-05-2

    L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

    J&H Chemical is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other

  •  Hangzhou J&H Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-87396432

    Address:No.200 Zhenhua Rd.Xihu Industrial Park, Hangzhou 310030, China

       Inquiry Now

  • Methotrexate 99% CAS NO.59-05-2

  • Casno:

    59-05-2

    Methotrexate 99% CAS NO.59-05-2

    Min.Order: 100 Gram

    FOB Price:  USD $ 100.0-2000.0

    We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

    SHANGHAI SYSTEAM BIOCHEM CO., LTD. is one of the professional suppliers in Chinese pharmaceutical market and is specialized in custom synthesis, chemical/pharmaceutical/ pesticides

  •  SHANGHAI SYSTEAM BIOCHEM CO., LTD

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-021-58380978

    Address:Building 87,Lane 669, Dong Jing Road Shanghai,P.R.China

       Inquiry Now

  • L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-

  • Casno:

    59-05-2

    L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Superior quality, moderate price & quick delivery. Appearance:yellow crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum or as per your request. Application:Used as a antineoplastic an

    Hangzhou Yunuo Chemical Co., Ltd. is located in Hangzhou City, China We are specialized in fine chemicals and basic chemical auxiliary materials, Organic compounds, rubber

  •  HANGZHOU YUNUO CHEMICAL CO.,LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:0571-83715115

    Address:hangzhou

       Inquiry Now

  • Methotrexate

  • Casno:

    59-05-2

    Methotrexate

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0

    Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

    TaiChem was established in 2015 and registered in China medical city - Taizhou, Jiangsu Province. The company has about 1800 square meters of class A plant facility. TaiChem focuse

  •  TaiChem Taizhou Limited

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-0523-86810091

    Address:Changjiang Dadao 18

       Inquiry Now

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 59-05-2

Chemistry

IUPAC Name: (2S)-2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioicacid
Following is the structure of Methotrexate (CAS NO.59-05-2):
                          
Empirical Formula: C20H22N8O5 
Molecular Weight: 454.44 g/mol 
EINECS: 200-413-8
Index of Refraction: 1.737
Molar Refractivity: 118.97 cm3
Molar Volume: 295.6 cm3
Density: 1.536 g/cm3
Melting point: 195 °C 
storage temp.: −20 °C
Polarizability: 47.16 10-24cm3
Surface Tension: 96.4 dyne/cm 
Water solubility: Insoluble. <0.1 g/100 mL at 19 °C
Appearance of Methotrexate (CAS NO.59-05-2): Yellow Crystaline Powder
Stability: Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
Product Categories: Aromatic Esters; Antibiotics for Research and Experimental Use; Antitumors for Research and Experimental Use; Biochemistry; Others (Antibiotics for Research and Experimental Use);Intermediates & Fine Chemicals; Pharmaceuticals; API's; Antitumour
Canonical SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Isomeric SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
InChIKey: FBOZXECLQNJBKD-ZDUSSCGKSA-N

History

  Methotrexate originated in the 1940s when Dr. Sidney Farber at Children's Hospital Boston was testing the effects of folic acid on acute leukemic (severe blood cancer) children.

Dr. Subbarao, who also happened to be the head of the team which had earlier synthesized folic acid (1946) readily synthesized this anti-folate and handed it over to Dr. Farber, who in turn administered it to a small group of very ill leukemic children.

The remarkable clinical improvement that was observed in these patients heralded the era of cancer chemotherapy in modern medicine. This was reported by Dr. S. Farber in the June 3rd, 1948 issue of NEJM.

In 1950 Dr. Farber founded in Boston the world's first Cancer Research Center. Methotrexate gained Food and Drug Administration (FDA) approval as an oncology drug in 1953.

Uses

 Methotrexate (CAS NO.59-05-2) was originally used as part of combination chemotherapy regimens to treat many kinds of cancers. It is commonly used (generally in combination with misoprostol) to terminate early pregnancies (i.e. as an abortifacient). It is also used to treat ectopic pregnancies. It has come into use as a treatment for some autoimmune diseases, including polymyositis, dermatomyositis, inclusion body myositis, ankylosing spondylitis, Crohn's disease, psoriasis, pustular psoriasis, psoriatic arthritis, rheumatoid arthritis, and scleroderma (see disease-modifying antirheumatic drugs). It also can be used as a antineoplastic and antirheumatic.Or can be used as a folic Acid antagonist.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 100mg/kg/4H (100mg/kg) BLOOD: THROMBOCYTOPENIA

BLOOD: OTHER CHANGES
Cancer Vol. 33, Pg. 1151, 1974.
child TDLo oral 2mg/kg/12D (2mg/kg) LUNGS, THORAX, OR RESPIRATION: COUGH

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
JAMA, Journal of the American Medical Association. Vol. 209, Pg. 1861, 1969.
human TDLo intramuscular 35mg/kg/28W (35mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
British Medical Journal. Vol. 2, Pg. 156, 1970.
human TDLo intramuscular 200mg/kg/5Y (200mg/kg) LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" Archives of Dermatology. Vol. 100, Pg. 531, 1969.
human TDLo intravenous 4650ug/kg/4W- (4.65mg/kg) LIVER: FATTY LIVER DEGERATION

LIVER: LIVER FUNCTION TESTS IMPAIRED
Proceedings of the American Association for Cancer Research. Vol. 5, Pg. 26, 1964.
human TDLo intravenous 7143ug/kg (7.143mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: CHANGES IN PLATELET COUNT

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 673, 1992.
human TDLo oral 43mg/kg/5Y (43mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED

LIVER: OTHER CHANGES
Archives of Dermatology. Vol. 100, Pg. 523, 1969.
man TDLo intramuscular 214ug/kg/12D- (0.214mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Clinical and Experimental Rheumatology. Vol. 14, Pg. 450, 1996.
man TDLo intravenous 740mg/kg (740mg/kg) GASTROINTESTINAL: OTHER CHANGES Archives of Internal Medicine. Vol. 136, Pg. 1321, 1976.
man TDLo oral 643ug/kg/6W-I (0.643mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Rheumatology. Vol. 14, Pg. 74, 1987.
man TDLo oral 4286ug/kg/2.7 (4.286mg/kg) LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION

BLOOD: APLASTIC ANEMIA
Clinical Rheumatology. Vol. 12, Pg. 535, 1993.
mouse LD50 intraperitoneal 50mg/kg (50mg/kg)   Anatomical Record. Vol. 178, Pg. 465, 1974.
mouse LD50 intravenous 65mg/kg (65mg/kg)   Drugs in Japan Vol. 6, Pg. 841, 1982.
mouse LD50 oral 146mg/kg (146mg/kg)   Drugs in Japan Vol. 6, Pg. 841, 1982.
mouse LD50 subcutaneous 250mg/kg (250mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 unreported 69mg/kg (69mg/kg)   Cancer Research. Vol. 46, Pg. 2703, 1986.
Link to PubMed
rat LD50 intraperitoneal 6mg/kg (6mg/kg)   Drugs in Japan Vol. 6, Pg. 841, 1982.
rat LD50 intravenous 14mg/kg (14mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970.
Link to PubMed
rat LD50 oral 135mg/kg (135mg/kg)   Drugs in Japan Vol. 6, Pg. 841, 1982.
rat LD50 subcutaneous 58mg/kg (58mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 unreported 133ug/kg (0.133mg/kg)   United States Patent Document. Vol. #4746662,
women LDLo intraspinal 36mg/kg/15D (36mg/kg) SPINAL CORD: OTHER DEGENERATIVE CHANGES

GASTROINTESTINAL: NAUSEA OR VOMITING
New England Journal of Medicine. Vol. 289, Pg. 770, 1973.
women TDLo oral 800ug/kg/4D-I (0.8mg/kg) BLOOD: LEUKOPENIA

BLOOD: THROMBOCYTOPENIA

BLOOD: OXIDANT RELATED (GPD DEFICIENT) ANEMIA
Medical Journal of Australia. Vol. 155, Pg. 493, 1991.
women TDLo oral 2mg/kg/17W-I (2mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: LEUKOPENIA
Journal of Rheumatology. Vol. 14, Pg. 74, 1987.
women TDLo parenteral 2600ug/kg (2.6mg/kg) BRAIN AND COVERINGS: CHANGES IN CEREBRAL SPINAL FLUID

LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cancer Vol. 38, Pg. 1529, 1976.
women TDLo unreported 11400ug/kg/44 (11.4mg/kg) LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" Clinical and Experimental Rheumatology. Vol. 15, Pg. 583, 1997.
women TDLo unreported 150mg/kg (150mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Cancer Vol. 48, Pg. 2158, 1981.

Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 241.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 267.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 267.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); No Evidence: mouse, rat CANCAR    Cancer. 40 (1977),1935. . Reported in EPA TSCA Inventory.

Safety Profile

A human poison by intraspinal route. Poison experimentally by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Human teratogenic effects by ingestion: developmental abnormalities of the craniofacial area and the musculoskeletal system. Human systemic effects by multiple routes: thrombocytopenia (decrease in the number of blood platelets), bone marrow changes, other blood changes, cerebral spinal fluid effects, eye effects, blood pressure lowering, cough, dyspnea, fibrosis (pneumoconiosis), cyanosis, gastrointestinal effects, fatty liver degeneration, hepatitis, impairment of liver function tests, other liver changes, fever, effects on inflammation or mediation of inflammation, leukopenia. Human mutation data reported. Experimental reproductive effects. A human eye irritant. Questionable human carcinogen producing leukemia, Hodgkin's disease, and skin tumors. An FDA proprietary drug. A chemotherapeutic agent. When heated to decomposition it emits toxic fumes including NOx.
Hazard Codes: ToxicT
Risk Statements: 61-25-36/38-46 
R61: May cause harm to the unborn child. 
R25: Toxic if swallowed. 
R36/38: Irritating to eyes and skin. 
R46: May cause heritable genetic damage.
Safety Statements: 53-26-36/37-45-36/37/39
S53: Avoid exposure - obtain special instructions before use. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37: Wear suitable protective clothing and gloves. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MA1225000
F: 3-8-10
HazardClass: 6.1(b)
PackingGroup: III

Specification

 Methotrexate , its cas register number 59-05-2. It also can be called  4-Amino-10-methylfolic acid ; 4-Amino-N(sup 10)-methylpteroylglutamic acid ; 4-Aminomethylpteroylglutamic acid ; A-Methopterin ; A-Methpterin ; Abitrexate ; Amethopterin ; Amethopterin L- ; Antifolan ; Brimexate ; Emtexate ; Emthexat ; Emthexate ; Farmitrexat ; Fauldexato ; Folex ; Folex PFS ; Folex-Pfs ; Kyselina 4-amino-N(sup 10)-methylpteroylglutamova ; Kyselina 4-amino-N(sup 10)-methylpteroylglutamova [Czech] ; Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)-L-glutamova ; Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)-L-glutamova [Czech] ; L-(+)-N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)glutamic acid ; L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl) ethylamino)benzoyl)- ; Lantarel ; Ledertrexate ; Lumexon ; Maxtrex ; Metatrexan ; Methoblastin ; Methotrexat-Ebewe ; Methotrexate ; Methotrexate LPF ; Methotrexate, L- ; Methotrexatum ; Methotrexatum [INN-Latin] ; Methylaminopterin ; Methylaminopterinum ; Metotressato ; Metotressato [DCIT] ; Metotrexato ; Metotrexato [INN-Spanish] ; Metrotex ; Mexate ; Mexate-AQ ; N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamicacid ; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-(+)-glutamic acid ; N-(p-(((2,4-Diamino-6-pteridyl)methyl)methylamino)benzoyl)glutamic acid ; N-Bismethylpteroylglutamic acid ; Novatrex ; Rheumatrex ; Texate ; Tremetex ; Trexeron ; Trixilem ; UNII-YL5FZ2Y5U1 ; and alpha-Methopterin . 
Its classification code are Abortifacient Agents; Abortifacient agents, nonsteroidal; Agricultural Chemical; Antimetabolites; Antimetabolites, antineoplastic; Antineoplastic; Antineoplastic Agents; Antirheumatic agents; Dermatologic agents; Drug / Therapeutic Agent; Enzyme inhibitors; Folic acid antagonists; Human Data; Immunologic Factors; Immunosuppressive agents; Insecticide; Mutation data; Noxae; Nucleic acid synthesis inhibitors; Reproductive Control Agents; Reproductive Effect; Skin / Eye Irritant and Tumor data.