Ciprofloxacin base/HCL CAS NO.86483-48-9

ciprofloxacin hydrochloride

melting point> 300 ° c

cas database 86483-48-9 (cas database reference)

ciprofloxacin hydrochloride use and synthesis

chemical properties white or slightly yellow crystalline powder. melting point 255-257 ° c (decomposition).

use of the goods is quinolone antibacterial one of the outstanding representatives of the german bayer pharmaceutical factory in 1983 successfully developed quinolone antibacterial agent of the first generation of nalidixic acid as the representative of the second generation of pipiic acid as the representative, the third generation is represented by norfloxacin. ciprofloxacin has broad antibacterial activity and strong antibacterial activity. it is effective against gram-positive bacteria and gram-negative bacteria. it is also effective for pseudomonas aeruginosa and has less adverse reactions. is the international market sales of large varieties of drugs, the rapid development of domestic production.

use of broad-spectrum antimicrobial agents, suitable for re-mixed infection, mainly for chronic respiratory tract, e. coli drugs, infectious rhinitis, poultry cholera, avian typhoid

production method 3-chloro-4-fluoroaniline diazotization, replacement, the formation of 2,4-dichlorofluorobenzene, and then acetylated 2,4-dichloro-5-fluoroacetophenone, with carbonic acid diethyl ester, 2,4-dichloro-5-fluorobenzoylacetate was prepared and reacted stepwise with triethyl orthoformate, acetic anhydride and cyclopropylamine to give 2- (3,4-dichloro- 5-fluorobenzoyl) -3-cyclopropylideneacrylate, which was reacted with nah in anhydrous dioxane and refluxed for 2 h to give 1-cyclopropyl-7-chloro-6-fluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid, followed by reaction with piperazine.