Icariin 98%MIN 489-32-7 competitive price 489-32-7 factory CAS NO.489-32-7

icariin is an inhibitor of human recombinant pde5 with an ic₅₀ value of 5.9 μm. it is a prenylated flavonol that has been shown to have anti-cancer and antioxidant activity. at a concentration of 1 x 107 mol/l, icariin induces differentiation of cardiomyocytes and upregulates the expression of cardiac genes. at 20 μg/ml, icariin increases the proliferation and differentiation of cultured human osteoblasts, which appears to be mediated in part by upregulating bone morphogenetic protein 2 mrna.

icariin, a type of flavonoid, is the major bioactive component in herba epimedii which has been historically used in combination with other herbs to treat skeletal diseases in traditional chinese medicine (tcm). it has been reported that icariin shows various pharmacological effects such as osteoprotective effect, antioxidative effect, osteoprotective effect, neuroprotective effect, cardiovascular protective effect, anti-cancer effect, anti-inflammation effect, immunoprotective effect and reproductive function.