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Shanghai Minstar Chemical Co., LtdLansoprazole 103577-45-3//www.lookchem.com/300w/\2010-5\9fb1dd5d-dc55-4201-882c-7503b7cc05f1.png

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Lansoprazole 103577-45-3 CAS NO.103577-45-3

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1 Kilogram
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Product Details


  • 103577-45-3
  • Lansoprazole

Quick Details

  • ProName: Lansoprazole 103577-45-3
  • CasNo: 103577-45-3
  • Molecular Formula: C16H14F3N3O2S
  • Appearance: White Crystalline Powder
  • Application: A H+,K+-ATPase inhibitor that displays...
  • DeliveryTime: in stock
  • PackAge: drums
  • Port: Shanghai
  • ProductionCapacity: 500 Kilogram/Month
  • Purity: 99%
  • Storage: dry and cool
  • Transportation: air, courier and sea
  • LimitNum: 1 Kilogram


synonyms: lansoprazole, related compound a2-[[[3-methyl-4-(2,2,2-triflouroethoxy)-2-pyridyl]methyl]sulfonyl]benzimidazole usp standard;lansoprazole, mm(crm standard);lansoprazole usp(crm standard);2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-1h-benzoimidazole;lansoprazole99.5%;a-65006, ag-1749, agopton, lansox, lanzor, limpidex, ogast, prevacid,;1h-benzimidazole, 2-3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinylmethylsulfinyl-;lansorazole
cas: 103577-45-3
mf: c16h14f3n3o2s
mw: 369.36
product categories: active pharmaceutical ingredients;intermediates & fine chemicals;pharmaceuticals;sulfur & selenium compounds;ion pump inhibitors;monovalent ion channels;voltage-gated ion channels;atpase;pharmaceutical intermediates;api reference standardfree base api;other apis;pharmaceutical
mol file: 103577-45-3.mol
lansoprazole structure
lansoprazole chemical properties
melting point 178-182°c dec.
storage temp. 2-8°c
form powder
color off-white
cas database reference 103577-45-3(cas database reference)
safety information
hazard codes xi
risk statements 36/37/38
safety statements 26-36
wgk germany 2
rtecs dd9487500
hazardous substances data 103577-45-3(hazardous substances data)


brief introduction lansoprazole is in a class of drugs called proton pump inhibitors (ppi) which prevent the stomach from producing gastric acid.the other drugs in ppi family include:
rabeprazole (aciphex),
omeprazole (prilosec),
pantoprazole (protonix),
esomeprazole (nexium).
proton pump inhibitors are used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (gerd) and zollinger-ellison syndrome that are caused by stomach acid. lansoprazole, like other proton-pump inhibitors, blocks the enzyme in the
wall of the stomach that produces acid. by blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal.
gastric acid secretion inhibitor r-(+)-lansoprazole is the dextroisomer of lansoprazole and a kind of anti-ulcer drug. it is the substitution product of benzimidazole derivative byimporting the fluorine element in the molecular structure and the is the second proton pump inhibitor after omeprazole. r-(+)-lansoprazole has a better inhibitory effect for gastric acid secretion than that of other drugs (omeprazole, pantoprazole, rabeprazole) and it can significantly inhibit ulcer. it has a better curative effect for ethanol-induced gastric mucosa lesion and acid hypersecretion induced duodenal ulcer than that of famotidine and omeprazole. in addition, this product also has an anti-helicobacter pylori effect similar to that of bismuth preparations and can be used to treat reflux esophagitis and zollinger-ellison syndrome.
r-(+)-lansoprazole can transform into active sulfonamide derivatives. in the tubule acidic environment of parietal cells, which are connected to the sulfydryl of h+-k+-(atp)adenosine triphosphatase(the last step of the enzyme catalyzed gastric acid secretion process),passivat h+-k+-atp enzyme and inhibit the gastric acid secretion regulated by central and peripheral nervous systems. the inhibition effect of gastric acid secretion of this product is at least as strong as omeprazole. in vivo studies of animal model have demonstrated that the inhibition effect for gastric acid secretion of r-(+)-lansoprazole is inferior to h2 receptor antagonist ranitidine and famotidine, but just as effective as omeprazole. unlike the h2 receptor antagonist, whether taken in the morning or evening, this product can inhibit gastric acid secretion during the day and night. it can also reduce the gastric acid secretion, inhibit the secretion of pepsin and its activity and clear pyloric campylobacter on gastric mucosa (a bacterium of causing recurrence. of peptic ulcer).
it can also be used to treat helicobacter pylori infection, alongside antibiotics as adjunctive treatment, to kill h. pylori causing ulcers or other problems involves using two other drugs known as "triple therapy", and involves taking twice daily for 10 or 14 days lansoprazole, amoxicillin, and clarithromycin.
pharmacokinetics when this product transform into active ag-1812 and ag-2000, r-(+)-lansoprazole in serum is metabolized quickly and completely into two main faeces: lansoprazole sulfone and hydroxy orchid sola. about 14%~23% of doses are excreted in the urine as conjugated and non-conjugated hydroxylation metabolites and no prototype of this product is found. the half-life of this product is 1.3~1.7 h, about 2 h for elderly people and as long as 7 h for patients with severe liver failure. the peak blood concentration can reach 1038μg/l within 2 h after taking 30 mg enteric capsules of this product.

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