Methyl acetoacetate CAS NO.105-45-3

product name:

methyl acetoacetate

synonyms:

3-oxbutanoic acid methyl ester;3-oxobutanoic acid methyl ester;3-oxobutyric acid methyl ester;acetyl methyl acetate;acetoacetic acid methyl ester;acetoacetic ester (methyl);acm;maa

cas:

105-45-3

mf:

c5h8o3

mw:

116.12

product categories:

building blocks;c2 to c5;carbonyl compounds;chemical synthesis;esters;organic building blocks;organic synthesis

mol file:

105-45-3.mol

chemical properties

melting point

-28 °c

boiling point

169-170 °c70 mm hg(lit.)

density

1.077

refractive index

n20/d 1.419(lit.)

fp

158 °f

storage temp.

2-8°c

solubility

460 g/l (20°c)

water solubility

460 g/l (20 ºc)

usage and synthesis

chemical properties

colorless, clear liquid

usage

methyl acetoacetate (maa) is a starting material for the syntheses of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.

3-oxobutanoic acid methyl ester is a chemical reagent used in the synthesis of pharmaceuticals. it participates in the biginelli reaction, forming molecules including dihydropyrimidinones.

general description

a clear colorless liquid. flash point 158°f. denser than water and slightly soluble in water. vapors heavier than air.

air & water reactions

very slightly soluble in water.

health hazard

may be harmful by inhalation, ingestion, or skin absorption. causes eye irritation. may cause skin irritation.