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HENAN SUNLAKE ENTERPRISE CORPORATIONPolymyxin B sulfate//www.lookchem.com/300w/201001/img/1405-20-5.jpg
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Polymyxin B sulfate CAS NO.1405-20-5

Min.Order Quantity:
1 Kilogram
Purity:
98%
Port:
TIANJIN/SHANGHAI
Payment Terms:
L/C,T/T

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Product Details

Keywords

  • POLYMYXIN B
  • POLYMYXIN-B 2,5-SULFATE
  • POLYMYXIN B SULFATE

Quick Details

  • ProName: Polymyxin B sulfate
  • CasNo: 1405-20-5
  • Molecular Formula: C56H100N16O17S
  • Appearance: White Solid
  • Application: Biochemical studies.
  • DeliveryTime: within 7-10days
  • PackAge: as required
  • Port: TIANJIN/SHANGHAI
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 98%
  • Storage: 2-8°C
  • Transportation: by air/ by sea/ by express
  • LimitNum: 1 Kilogram

Superiority

polymyxin b sulfate chemical properties
mp 217-220°c (dec.)
storage temp. 2-8°c
solubility h2o: 50 mg/ml
form powder
merck 13,7656
cas database reference 1405-20-5(cas database reference)
epa substance registry system polymyxin b, sulfate(1405-20-5)
safety information
hazard codes xn
risk statements 22
safety statements 22-24/25
ridadr 3249
wgk germany 3
rtecs tr1150000
f 3-8-10
hazardclass 6.1(b)
packinggroup iii
msds information
provider language
sigmaaldrich english
polymyxin b sulfate usage and synthesis
indications polymyxin b sulfate is similar with polymyxin e, and has either bacteriostatic or bactericidal effect on various kinds of gram-negative bacteria, such as escherichia coli, pseudomonas aeruginosa, escherichia coli deputy, klebsiella pneumoniae, acidophilus, bordetella pertussis and shigella dysentery. it is mainly applied to the treatment of infection in wounds, the urinary tract, eyes, ears, and bronchus caused by pseudomonas aeruginosa and other kinds of pseudomonas. it can also be applied for treating sepsis, peritonitis, and severe infection caused by aminoglycoside-resistant, third generation cephalosporins-resistant bacteria and pseudomonas aeruginosa or other sensitive strains, such as bacteremia, endocarditis, pneumonia, and burn infection.
dosage 1. intravenous injection: adults and children with normal renal function: 1.5 to 2.5 mg per kilogram of body weight per day (for per kg body weight, generally apply not more than 2.5 mg), divide into 2 times with 1 time every 12 hours of infusion. dilute every 50mg of the product with 500 ml of 5% glucose solution and further add drop wise. babies with normal renal function can tolerate a amount of 4 mg/day per kilogram of body weight.
2. intramuscular injection: adults and children: apply 2.5 to 3 mg per kilogram of body weight; apply in divided doses with applying 1 time every 4 to 6 hours. for baby, the dosage can be 4 mg per day per kilogram of body weight. for new born children, we can apply to 4.5 mg per time per kilogram of body weight.
3. intrathecal injection (for pseudomonas aeruginosa meningitis): each ml of drug solution prepared by the sodium chloride injection contains 5mg. adults and children with over 2 years of age, apply 5 mg daily; after application of 3 to 4 days, change one time every other day, and continue for at least 2 weeks until the result of cerebrospinal fluid culture becomes negative and the sugar inspection becomes normal. for children less than 2 years of age, apply 2mg 1 time per day for continuous 3 to 4 days (or 2.5mg per every other day); after that, apply 2.5mg every other day, until the test becomes normal.
4. the ophthalmic solution concentration: 1 ~ 2.5mg per milliliter.
drug interactions we should avoid apply it in combination with drugs causing significant damage to the kidneys, skeletal muscle relaxants, aminoglycoside antibiotics, and anesthetic drugs with significant effect of muscle relaxation (such as enflurane). also we should avoid simultaneous intravenous administration of quinine, and magnesium. combining polymyxin b sulfate with sulfa drugs, rifampicin, and semi-synthetic penicillin has a better efficacy than single application in treating severe infections resistant gram-negative bacteria.
the above information is edited by the chemicalbook of dai xiongfeng.
injection polymyxin b sulfate manufacturer shanghai “xin xianfeng” pharmaceutical co., ltd. zhunzi h31022973
shanghai no. 1 biochemical pharmaceutical co., ltd. zhunzi h31022631
precautions 1. pregnant and lactating women, children, patients with severe kidneys damage and severe kidney dysfunction should either take with caution or reduce the administrated amount.
2. this product has relative large toxicity and a poor efficacy in treating deep tissue infection. it is also not the primary choice of drug for treating any kinds of infection.
3. intravenous injection may lead to respiratory depression and thus should generally not used. half of the amount in daily dose should subject to intravenous drip, and can’t subject to disposable rapid bolus avoid extensive neuromuscular blockade.
4. it shouldn’t be used in combination with drugs with other renal toxicity or neuromuscular blocking effects to avoid accidents.
application biochemical studies.
polymyxin b is a kind of anti-gram-negative poly-peptide antibiotics which can alter membrane structure allowing small molecules leakage and inhibit the growth of gram-negative bacteria. it has bactericidal effect on escherichia coli through binding to the lipid a portion of bacterial lipopolysaccharide. mechanism of action: bind and interfere with the permeability o the cellular membrane. anti-bacteria spectrum: gram negative bacteria.
chemical properties white solid
usage antibacterial
usage antibiotic with bactericidal action on e. coli. binds to the lipid a portion of bacterial lipopolysaccharides. induces pore formation in the membranes of cortex cells from excised sorghum roots. mixtu re of polymyxin b1 and b2 sulfate. biological potency (dry basis): >6000u/mg.

Details

product information

1)basic information

2)chemical properties
mp 217-220°c (dec.)
storage temp. 2-8°c
solubility h2o: 50 mg/ml
form powder
merck 13,7656
cas database reference 1405-20-5(cas database reference)
epa substance registry system polymyxin b, sulfate(1405-20-5)
3)safety information
hazard codes xn
risk statements 22
safety statements 22-24/25
ridadr 3249
wgk germany 3
rtecs tr1150000
f 3-8-10
hazardclass 6.1(b)
packinggroup iii

4)usage and synthesis

indications polymyxin b sulfate is similar with polymyxin e, and has either bacteriostatic or bactericidal effect on various kinds of gram-negative bacteria, such as escherichia coli, pseudomonas aeruginosa, escherichia coli deputy, klebsiella pneumoniae, acidophilus, bordetella pertussis and shigella dysentery. it is mainly applied to the treatment of infection in wounds, the urinary tract, eyes, ears, and bronchus caused by pseudomonas aeruginosa and other kinds of pseudomonas. it can also be applied for treating sepsis, peritonitis, and severe infection caused by aminoglycoside-resistant, third generation cephalosporins-resistant bacteria and pseudomonas aeruginosa or other sensitive strains, such as bacteremia, endocarditis, pneumonia, and burn infection.
dosage 1. intravenous injection: adults and children with normal renal function: 1.5 to 2.5 mg per kilogram of body weight per day (for per kg body weight, generally apply not more than 2.5 mg), divide into 2 times with 1 time every 12 hours of infusion. dilute every 50mg of the product with 500 ml of 5% glucose solution and further add drop wise. babies with normal renal function can tolerate a amount of 4 mg/day per kilogram of body weight.
2. intramuscular injection: adults and children: apply 2.5 to 3 mg per kilogram of body weight; apply in divided doses with applying 1 time every 4 to 6 hours. for baby, the dosage can be 4 mg per day per kilogram of body weight. for new born children, we can apply to 4.5 mg per time per kilogram of body weight.
3. intrathecal injection (for pseudomonas aeruginosa meningitis): each ml of drug solution prepared by the sodium chloride injection contains 5mg. adults and children with over 2 years of age, apply 5 mg daily; after application of 3 to 4 days, change one time every other day, and continue for at least 2 weeks until the result of cerebrospinal fluid culture becomes negative and the sugar inspection becomes normal. for children less than 2 years of age, apply 2mg 1 time per day for continuous 3 to 4 days (or 2.5mg per every other day); after that, apply 2.5mg every other day, until the test becomes normal.
4. the ophthalmic solution concentration: 1 ~ 2.5mg per milliliter.
drug interactions we should avoid apply it in combination with drugs causing significant damage to the kidneys, skeletal muscle relaxants, aminoglycoside antibiotics, and anesthetic drugs with significant effect of muscle relaxation (such as enflurane). also we should avoid simultaneous intravenous administration of quinine, and magnesium. combining polymyxin b sulfate with sulfa drugs, rifampicin, and semi-synthetic penicillin has a better efficacy than single application in treating severe infections resistant gram-negative bacteria.
the above information is edited by the chemicalbook of dai xiongfeng.
injection polymyxin b sulfate manufacturer shanghai “xin xianfeng” pharmaceutical co., ltd. zhunzi h31022973
shanghai no. 1 biochemical pharmaceutical co., ltd. zhunzi h31022631
precautions 1. pregnant and lactating women, children, patients with severe kidneys damage and severe kidney dysfunction should either take with caution or reduce the administrated amount.
2. this product has relative large toxicity and a poor efficacy in treating deep tissue infection. it is also not the primary choice of drug for treating any kinds of infection.
3. intravenous injection may lead to respiratory depression and thus should generally not used. half of the amount in daily dose should subject to intravenous drip, and can’t subject to disposable rapid bolus avoid extensive neuromuscular blockade.
4. it shouldn’t be used in combination with drugs with other renal toxicity or neuromuscular blocking effects to avoid accidents.
application biochemical studies.
polymyxin b is a kind of anti-gram-negative poly-peptide antibiotics which can alter membrane structure allowing small molecules leakage and inhibit the growth of gram-negative bacteria. it has bactericidal effect on escherichia coli through binding to the lipid a portion of bacterial lipopolysaccharide. mechanism of action: bind and interfere with the permeability o the cellular membrane. anti-bacteria spectrum: gram negative bacteria.
chemical properties white solid
usage antibacterial
usage antibiotic with bactericidal action on e. coli. binds to the lipid a portion of bacterial lipopolysaccharides. induces pore formation in the membranes of cortex cells from excised sorghum roots. mixtu re of polymyxin b1 and b2 sulfate. biological potency (dry basis): >6000u/mg.

company information

henan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.

we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team, who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team.

we are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

we welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.

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