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Pyrimethamine CAS NO.58-14-0

Min.Order Quantity:
1 Kilogram
Purity:
99%
Port:
Shanghai/Tianjin/Qingdao
Payment Terms:
L/C,D/A,D/P,T/T,

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Product Details

Keywords

  • 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine
  • 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine
  • 2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-

Quick Details

  • ProName: Pyrimethamine
  • CasNo: 58-14-0
  • Molecular Formula: C12H13ClN4
  • Appearance: White Solid
  • Application: 58-14-0 ...
  • DeliveryTime: 7-10 days after payment
  • PackAge: As required
  • Port: Shanghai/Tianjin/Qingdao
  • ProductionCapacity: 100-200 Kilogram/Month
  • Purity: 99%
  • Storage: 0-6°C
  • Transportation: By air/sea/express
  • LimitNum: 1 Kilogram
  • Grade: Pharma Grade

Superiority

about certificate

1.certificate of analysis (coa)
2.material safety data sheet (msds)
3.route of synthesis (ros)
4.method of aanlysis(moa)
5.nuclear magnetic resonance(nmr)

about service

1. quality control, before shipment, free sample for test.
2. prompt shipment with professional documents
3. packing as your request, with photo before shipment
4. mixed containers with different mixed items in one container

about company

hennan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.
we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team, who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team.
we are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.
we welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details

product name: pyrimethamine
synonyms: 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;2,4-diamino-5-chlorophenyl-6-ethylpyrimidine;2,4-pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-;2,4-pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-;2,4-pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;4753 r.p.;4753r.p.;5-(4’-chlorophenyl)-2,4-diamino-6-ethylpyrimidine
cas: 58-14-0
mf: c12h13cln4
mw: 248.71
einecs: 200-364-2
product categories: apis & intermediate;pyrimidine;organics;amines;bases & related reagents;heterocycles;intermediates & fine chemicals;nucleotides;pharmaceuticals;inhibitor;heterocycle-pyrimidine series;daraprim
mol file: 58-14-0.mol
pyrimethamine structure
pyrimethamine chemical properties
mp 233-234°c
storage temp. 0-6°c
water solubility <0.01 g/100 ml at 21 ºc
stability: stable, but light sensitive. combustible. incompatible with strong oxidizing agents.
cas database reference 58-14-0(cas database reference)
nist chemistry reference pyrimethamine(58-14-0)
epa substance registry system 2,4-pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl- (58-14-0)
safety information
hazard codes xn
risk statements 22
ridadr 3249
wgk germany 3
rtecs uv8140000
hazardclass 6.1(b)
packinggroup iii
msds information
pyrimethamine usage and synthesis
chemical properties white solid
usage dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. antiprotozoal (toxoplasma); antimalarial
usage for the treatment of toxoplasmosis and acute malaria; for the prevention of malaria in areas non-resistant to pyrimethamine
general description odorless white crystalline powder. tasteless. an antimalarial drug.
air & water reactions insoluble in water.
reactivity profile pyrimethamine is sensitive to exposure to light . neutralizes acids to form salts plus water in exothermic reactions. may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
fire hazard flash point data for pyrimethamine are not available; however, pyrimethamine is probably combustible.
biological activity potent inhibitor of multi-drug and toxin extrusion (mate) transporters (k i values are 46 and 77 nm for human mate2-k-hek293 and mate1-hek293 cells respectively). also inhibits dihydrofolate reductase (dhfr).
pyrimethamine preparation products and raw materials
raw materials ethyl propionate-->4-chlorobenzyl cyanide

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