product name: β–amyloid (1-42),human,amyloid β-protein (human, 1-42),beta-amyloid (1- 42) human
cas no: 107761-42-2
sequence:
{asp}{ala}{glu}{phe}{arg}{his}{asp}{ser}{gly}{tyr}{glu}{val}
{his}{his}{gln}{lys}{leu}{val}{phe}{phe}{ala}{glu}{asp}{val}
{gly}{ser}{asn}{lys}{gly}{ala}{ile}{ile}{gly}{leu}{met}{val}
{gly}{gly}{val}{val}{ile}{ala}
sequence shortening:daefrhdsgyevhhqklvffaedvgsnkgaiiglmvggvvia
molecular formula:c203h311n55o60s1
molecular weight:4514.1
description
this peptide is well suited to the quantitative determination of a 42 peptide. alzheimer’s disease (ad) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (nfts) in the brain. the major protein component of these plaques is beta amyloid peptide (a), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (bace) and a putative (gamma) secretase. increased release of the ‘longer forms’ of a peptide, a 42 and a 43, which have a greater tendency to aggregate than a 40, occurs in individuals expressing certain genetic mutations, expressing certain apoe alleles or may other, still undiscovered factors.
properties
purity: > 98%
solubility:soluble in water
storage: store at -20°c