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SWAINSONINE CAS NO.72741-87-8

Min.Order Quantity:
100 Kilogram
Purity:
99%
Port:
China Main Port
Payment Terms:
L/C,D/A,D/P,T/T,Other

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Product Details

Keywords

  • SWAINSONINE
  • 72741-87-8
  • C8H15NO3

Quick Details

  • ProName: SWAINSONINE
  • CasNo: 72741-87-8
  • Molecular Formula: C8H15NO3
  • Appearance: powder
  • Application: 72741-87-8
  • DeliveryTime: Within 3-7 days
  • PackAge: Depended
  • Port: China Main Port
  • ProductionCapacity: 300 Kilogram/Month
  • Purity: 99%
  • Storage: Store in dry, dark and ventilated plac...
  • Transportation: by air or by sea
  • LimitNum: 100 Kilogram
  • Application: Multipurpose intermediate
  • Application: ISO/9001 Certificate

Superiority

swainsonine basic information
product name: swainsonine
synonyms: swainsonine;swainsonine, swainsona canescens;8-indolizinetriol(1s-(1-alpha,2-alpha,8-beta,8a-beta))-octahydro-2;8-indolizinetriol,octahydro-,(1s-(1-alpha,2-alpha,8-beta,8a-beta))-2;8-indolizinetriol,octahydro-,(1s,2r,8r,8ar)-2;(1s,2s,8r,8ar)-trihydroxyindolizidine;(1s,2r,8r,8ar)-1,2,8-octahydroindolizidinetriol;8alpha,beta-indolizidine-1,2alpha,8beta-triol
cas: 72741-87-8
mf: c8h15no3
mw: 173.21
einecs:
product categories: alkaloids;glycosidase inhibitors;inhibitors
mol file: 72741-87-8.mol
swainsonine structure
swainsonine chemical properties
mp 148-149°c
density 1.38±0.1 g/cm3 (20 ºc 760 torr)
storage temp. 2-8°c
form lyophilized powder
safety information
hazard codes xn
risk statements 20/21/22
safety statements 36
wgk germany 3
rtecs nm2408666
msds information
provider language
sigmaaldrich english
swainsonine usage and synthesis
chemical properties white crystalline solid
usage swainsonine is a plant alkaloid derived from swainsona canescens (a leguminous plant). it is a reversible, active-site directed inhibitor of a-mannosidase at concentrations of 5-10mm. at acid ph, swainsonine resembles an intermediate in the hydrolysis of mannosidases. swainsonine completely inhibits mammalian golgi a-mannosidase ii (a-3/6-mannosidase in the glycoprotein processing pathway) and mammalian lysosomal a-mannosidase (acid mannosidase). at higher concentrations, swainsonine also inhibits mammalian cytosolic a-mannosidase. it has been shown to inhibit growth of transformed fibroblasts in soft agar and to enhance the antiproliferative effects of inf on murine lymphoreticular tumor cells in vitro. it also blocks the expression of b1-6 branched complex-type oligosaccharides and shunts the pathway towards hybrid-type oligosaccharides. swainsonine does not appear to inhibit secretion or expression of glycoproteins at the cell surface. swainsonine is stable for at least 24 h at 37oc in culture media at physiological ph. working concentration range is 17-1700 ng/ml (0.1-10mm). swainsonine (at 1 mg/ml) is not cytotoxic and does not inhibit the growth of a variety of mammalian cell lines. concentrations required to inhibit golgi a-mannosidase ii in vivo may be somewhat higher, as swainsonine tends to concentrate in the acid environment of cell lysosomes, where it exists as a charged cation and does not permeate through membranes readily. swainsonine blocks the processing of high-mannose oligosaccharides to complex oligosaccharides. glycoproteins synthesized in the presence of swainsonine tend to carry mostly high-mannose and hybrid oligosaccharide chains. with short treatments (<24 h) with the inhibitor, cells may retain some complex glycoproteins due to asynchronous cell growth and glycoprotein synthesis.
biological activity inhibitor of α -mannosidase ii which inhibits glycoprotein processing. displays anticancer and immune modulatory properties.

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