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sorafenib tosylate basic information |
product name: | sorafenib tosylate |
synonyms: | sorafenib;sorafenib-d3;sorafenib tolsylate;raf1 kinase inhibitor ii;n-(4-chloro-3-(trifluoromethyl)phenyl)-((4-(2-(n-methyl-carbamoyl)(4-pyridyloxy))phenyl)amino)carboxamide;4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methyl-pyridine-2-carboxamide;bay 43-9006;sorafenib mesylate |
cas: | 284461-73-0 |
mf: | c21h16clf3n4o3 |
mw: | 464.83 |
einecs: | |
product categories: | sorafinib;molecular targeted antineoplastic;all inhibitors;anti-neoplastic;inhibitors;intermediates & fine chemicals;pharmaceuticals;pharmaceutical intermediate;amines;inhibitor;bay 43-9006 |
mol file: | 284461-73-0.mol |
sorafenib tosylate chemical properties |
mp | 202-204°c |
storage temp. | -20°c freezer |
cas database reference | 284461-73-0(cas database reference) |
safety information |
sorafenib tosylate usage and synthesis |
chemical properties | light yellow solid |
usage | a potent raf kinase inhibitor. antineoplastic |
usage | multiple kinase inhibitor targeting both raf kinase and receptor tyrosine kinases that promote angiogensis. antineoplastic. |
usage | sorafenib tosylate (bay 43-9006, nexavar) is a small molecular inhibitor of vegfr, pdgfr, c-raf and b-raf with ic50s of 18 nm, 10 nm, 3 nm and 15 nm, respectively. |
usage | sorafenib tosylate (bay 43-9006) is a multikinase inhibitor of raf-1, b-raf and vegfr-2 with ic50 of 6 nm, 22 nm and 90 nm, respectively - see more at: # |
sorafenib tosylate preparation products and raw materials |