TIANFU CHEM Fludarabine CAS NO.21679-14-1

fludarabine basic information
product name: fludarabine
synonyms: 2-fluoroadeninearabinoside;9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin;9-beta-d-arabinofuranosyl-2-fluoro-adenin;f-ara-a;6-amino-9 beta-d-arabinofuranosylfluoropurine;9-bata-d-arabinofuranosyl-2-fluoroadenine;9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amine;9-beta-d-arabinofuranosyl-2-fluoroadenine
cas: 21679-14-1
mf: c10h12fn5o4
mw: 285.23
einecs: 244-525-5
product categories: intermediates & fine chemicals;pharmaceuticals;api;f-ara-a, nsc 118218;anti-cancer&immunity;inhibitors
mol file: 21679-14-1.mol
fludarabine structure
fludarabine chemical properties
melting point 265-268°c
alpha d25 +17 ±2.5° (c = 0.1 in ethanol)
storage temp. 2-8°c
solubility dmf: 20 mg/ml, clear, faintly yellow
form powder
color white to pale yellow
water solubility soluble in dmf, dmso, methanol or ethanol. sparingly soluble in water
merck 13,4152
cas database reference 21679-14-1(cas database reference)
safety information
hazard codes xn
risk statements 23/24/25-36/37/38-39/23/24/25-39-22
safety statements 26-36/37-45-36
wgk germany 3
rtecs au6207000
f 10
hazardous substances data 21679-14-1(hazardous substances data)

fludarabine usage and synthesis
chemical properties white solid
uses used as an antineoplastic
uses a stat-1 activation inhibitor and a dna synthesis inhibitor.
uses phosphate as antineoplastic;inhibits dna synthesis by interfering with ribonucleotide reductase and dna polymerase
uses irreversible muscarinic agonist
uses dna synthesis and methylation inhibitor;a cell permeable agent that interferes with dna synthesis and repair; also inhibits rna transcription
biological activity purine analog that inhibits dna synthesis. exhibits antiproliferative activity (ic 50 = 1.54 μ m in rpmi cells) and triggers apoptosis through increasing bax and decreasing bid, xiap and survivin expression. displays anticancer activity against hematological malignancies in vivo .