TIANFUCHEM--536-43-6--High purity Dyclonine hydrochloride factory price CAS NO.536-43-6

dyclonine hydrochloride

english synonyms: dyclonine hcl; dyclonine hydrochloride; labotest-bb lt00771942; 1- (4-butoxyphenyl) -3- (1 -piperidinyl) -1- propanone hcl; 1- (4-butoxyphenyl) -3- (1 -piperidinyl) -1-propanone hydrochloride; 1- (4-butoxyphenyl) -3- (1-piperidinyl) -1-propanonhydrochloride; 4'-butoxy-3-piperidinopropiophenone hydrochloride; 4'-butoxy-3-piperidino-propiophenonhydrochloride

cas number: 536-43-6

molecular formula: c18h28clno2

molecular weight: 325.87

einecs no. 208-633-6

related categories: active pharmaceutical ingredients; local anesthetics; intermediates & fine chemicals; pharmaceuticals; apis; antibiotics; apis; dyclone; topical anesthetics; pharmaceutical raw materials; intermediates; raw materials; small molecule inhibitors; pharmaceutical raw materials; other; research chemical

mol file: 536-43-6.mol

dacronine hydrochloride

dacronine hydrochloride nature

melting point 175-176 ° c

storage conditions -20 ° c freezer

partly soluble in water. soluble in chloroform, ethanol, acetone and methanol.

merck 14,3473

inchikey knzadimhvbbpoa-uhfffaoysa-n

cas database 536-43-6 (cas database reference)

usage and synthesis of dacronine hydrochloride

dyclonine hydrochloride, a local anesthetic, is also known as daclomide and its chemical name is 4-butoxy-β-piperidinylpropiophenone hydrochloride. it is a fast acting, long acting, adverse reaction small, safe local anesthetic. currently there are listed or reported dronedarone formulations mainly ointment, cream, liniment, solution, gel and emulsion-type mortar. among them, the top 5 are mainly for external use, the last one is for endoscopy, digestive tract and other endoscopic examination. clinical for mucosal surface anesthesia and skin pain, itching.

characters white crystalline powder, slightly smelly, taste a hemp sense, slightly soluble in water, soluble in ethanol, acetone, chloroform and water at 60 ℃. stable in the air, in case of hot decomposition solution becomes turbid precipitation of oil, confined dark protection.

pharmacodynamics mechanism is mainly nerve block, local anesthesia fast, strong pharmacological effects and long duration, toxicity, analgesic, antipruritic, bactericidal effect.

dacron hydrochloride solution

figure 1 is dacron hydrochloride solution

pharmacokinetic injection is irritant, only for the appearance of the mucosal penetrating power.

synthesis method piperidine hydrochloride and concentrated hydrochloric acid reaction of piperidine hydrochloride, to which was added p-butoxy acetophenone and paraformaldehyde, and then add concentrated hydrochloric acid as a catalyst to obtain crude dicalcium hydrochloride, the system hydrochloric acid dacronin crude dissolved in anhydrous ethanol, activated carbon was added, heated to reflux, hot filtration, the filtrate was stirred cold, suction filtration, dried in vacuo to give dacronin quality.

synthetic route of dacronine hydrochloride

figure 2 shows the synthetic route of dacronine hydrochloride

uses for burns, abrasions, prurigo, insect bites, ulcers, bedsores, hemorrhoids, etc., but also for urinary tract and dental mucosal anesthesia.

the properties, pharmacodynamics, synthetic methods, uses, etc., of dacronine hydrochloride were compiled and edited by shi yan, chemicalbook. (2015-12-02)

matters needing attention 1 to dacronine hydrochloride allergy disabled.

2. the elderly, acute patients, severe gastrointestinal mucosal injury and children reduce the dosage as appropriate.

3. caution for pregnant women and children must be used under the supervision of adults.

4. when the trait changes when disabled.

5. this medicine is out of the reach of children.

usage and dosage topical 1% ointment, cream, also used 0.5% solution, mucosal anesthesia with 1% solution 10ml.

formulation and specifications dubbed 0.5% ~ 1% solution; 1% ointment; 1% cream.

use for surface anesthesia.

category toxic substances

toxicity grade highly toxic

acute toxicity celiac - rat ld50: 33 mg / kg; celiac - mouse ld50: 52 mg / kg

irritation data skin - rabbit 1% mild; eye - rabbit 2% heavy

flammability hazardous characteristics thermal decomposition of toxic nitrogen oxides, hydrogen chloride smoke

storage and transportation warehouse ventilation low temperature drying

extinguishing agent water, dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent

security information

dangerous goods signs xn

hazard category code 22-37 / 38-41

safety instructions 26-36

dangerous goods transport number 3249

wgk germany 3

rtecs number ug8750000

hazardclass 6.1 (b)