TIANFUCHEM--55-98-1--High purity Busulfanfactory price CAS NO.55-98-1

busulfan

english synonyms: busulfan; busulfex; busulphan; 1,4-dimethanesulfonoxybutane; 1,4-bis (methyl sulfonoxy) butane; 1,4-butanediol dimethanesulfonate; 1,4-butanediol dimethyl sulfonate;

cas number: 55-98-1

molecular formula: c6h14o6s2

molecular weight: 246.3

einecs number: 200-250-2

related categories: antitumors for research and experimental use; biochemistry; intermediates & fine chemicals; pharmaceuticals; sulfur & selenium compounds; cell biology; myleran; pharmaceutical ingredients; antineoplastic agents and immunosuppressives; small molecules inhibitors; esters

mol file: 55-98-1.mol

white xia'an

white xiaoxian nature

melting point 114-117 ° c (lit.)

flash point 9 ℃

storage conditions hygroscopic, refrigerator, under inert atmosphere

form crystalline powder

color pale brown

water-solubility decomposes

merck 1505

stability moisture sensitive

cas database 55-98-1 (cas database reference)

epa chemical information 1,4-butanediol, dimethanesulfonate (55-98-1)

busulfan purposes and methods of synthesis

chemical properties of white crystalline powder. melting point 119 ℃. do not dissolve in water, but can slowly dissolve, hydrolysis occurs at the same time. solubility in acetone at 25 ℃ 2.4g / 100ml, solubility in ethanol 0.1g / 100ml, almost no smell.

use anti-cancer drugs. the goods for the non-specific cell cycle drugs, mainly for the g1 phase and m phase. the low dose of the product inhibits the formation of myeloid granulocytes, almost no effect on erythrocytes and lymphocytes. large doses of red blood cells and lymphocytes almost no effect. high doses of erythrocytes and lymphocytes inhibited. because of selective effects, the treatment of chronic myelogenous leukemia significant. busulfan is currently the treatment of chronic myeloid leukemia drugs, the remission rate of up to 80-90%. however, in the event of an acute change should be discontinued.

production methods methyl methanesulfonyl chloride and 1,4-butanediol condensation derived.

category toxic substances

toxicity grade highly toxic

acute toxicity intraperitoneal - rat ld50: 22 mg / kg; oral - mouse ld50: 110 mg / kg

flammability hazardous characteristics thermal decomposition of toxic sulfur oxide fumes

storage and transportation warehouse ventilation dry at low temperature; separated from oxidants and acids; not easy to store for a long time to prevent polymerization

extinguishing agent water, dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent

packing:

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