USD $1.00-1.00 / Kilogram
USD $2.00-10.00 / Kilogram
USD $2.00-10.00 / Kilogram
USD $2.00-10.00 / Kilogram
USD $2.00-10.00 / Kilogram
USD $2.00-10.00 / Kilogram
USD $10.00-16.00 / Kilogram
USD $1.00-1.00 / Kilogram
USD $1.00-1.00 / Kilogram
product name: | ucn-01 |
synonyms: | ucn-01;7-hydroxystaurosporine;kw-2401;(9s)-2,3,10,11,12,13-hexahydro-3α-hydroxy-10α-methoxy-9-methyl-11α-methylamino-9β,13β-epoxy-1h,9h-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one;9,13-epoxy-1h,9h-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3r,9s,10r,11r,13r)-;krx-0601;nsc 638850;unc 01 |
cas: | 112953-11-4 |
mf: | c28h26n4o4 |
mw: | 482.53044 |
einecs: | |
product categories: | |
mol file: | 112953-11-4.mol |
ucn-01 chemical properties |
storage temp. | 2-8°c |
safety information |
rtecs | kc6600010 |
ucn-01 usage and synthesis |
usage | ucn-01 is an indolocarbazole isolated from a high staurosporine-producing streptomyces culture. ucn-01 inhibits protein kinase c (pkc) and cyclin-dependant kinase 2 (cdk2), resulting in accumulation of cells in the g1 phase and induction of apoptosis. ucn-01 also enhances the cytotoxicity of other anti-cancer drugs, such as dna-damaging agents and anti-metabolite drugs, through putative abrogation of g2 and/or s phase accumulation induced by the latter agents. |