factory supply GMP,DMF Abacavir sulfate CAS NO.188062-50-2

Min.Order Quantity:: 1 Kilogram

Purity:: USP/EP/BP

Port:: SHANGHAI BEIJING

Payment Terms:: L/C,T/T,Other

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Product Details

Keywords

Abacavir sulfate
Abacavir
188062-50-2

Quick Details

ProName: factory supply GMP,DMF Abacavir sulfat...
CasNo: 188062-50-2
Molecular Formula: C8H10FN3O3S
Appearance: White crystallization
Application: anti-HIV drugs
DeliveryTime: in two weeks
PackAge: 1kg/tin
Port: SHANGHAI BEIJING
ProductionCapacity: 1 Metric Ton/Day
Purity: USP/EP/BP
Transportation: AIR SEA TRAIN
LimitNum: 1 Kilogram

Superiority

we are very compeitive on abacavir sulfate.our mfr is gmp certified for this item with dmf document.

product name:	abacavir sulfate
cas:	188062-50-2
mf:	c28h38n12o6s
mw:	670.74
einecs:	620-488-4
product categories:	api;ziagen;bases & related reagents;inhibitors;intermediates & fine chemicals;abacavir;antiviral agents;nucleotides;pharmaceuticals
mol file:	188062-50-2.mol

Details

abacavir sulfate chemical properties

melting point	222-225°c
storage temp.	2-8°c
solubility	h2o: ≥17mg/ml
form	powder
color	white to tan
optical activity	[α]/d -30 to -40°, c = 0.5 in methanol
water solubility	1.68ug/l(32 ºc)
cas database reference	188062-50-2(cas database reference)

safety information

hazard codes	xn
risk statements	63-40
safety statements	36/37
wgk germany	3
hs code	2933595960
hazardous substances data	188062-50-2(hazardous substances data)

abacavir sulfate usage and synthesis

description

abacavir sulfate was first launched as ziagen in the us for the treatment of human immunodeficiency virus (hiv) infection, in combination with other antiretroviral drugs. abacavir is a carbocyclic nucleoside reverse transcriptase inhibitor (nrti); it is one of the most potent anti-hiv agents to date. the compound can be prepared by an enantioselective synthesis involving palladium-catalyzed coupling of a chloropurine with a carbocyclic allylic diacetate. in vitro, abacavir is a potent and selective inhibitor of hiv-1 and hiv-2 replication. resistance to abacavir develops more slowly than for other anti-hiv agents. abacavir is highly synergistic with protease inhibitors such as amprenavir. in clinical trials for hiv infections in adults, it produced durable suppression in viral load. combinations with different protease inhibitors such as nelfinavir, saquinavir or indinavir markedly reduced plasma viral load to undetectable levels for at least 48 weeks, and significantly raised cd4+ cell counts in adults with hiv infection, especially nrti-naive patients. abacavir has a good oral availability and its penetration into csf is much more significant than for other anti-hiv drugs. the two major metabolites identified in humans were the 5'-carboxylate and the 5'-glucuronide, mainly excreted via the renal route.

chemical properties

white solid

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