losartan potassium chemical properties |
melting point |
263-265°c |
storage temp. |
inert atmosphere,room temperature |
solubility |
freely soluble in water and in methanol, slightly soluble in acetonitrile. |
form |
powder or crystals |
merck |
14,5583 |
brn |
5845770 |
cas database reference |
124750-99-8(cas database reference) |
hazard codes |
xi |
risk statements |
36/37/38 |
safety statements |
26-36/37/39 |
wgk germany |
3 |
rtecs |
ni6755100 |
hs code |
2933290000 |
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losartan potassium usage and synthesis |
description |
as a angiotensin ii receptor antagonist, losartan potassium is the potassium salt of losartan with antihypertensive activity, which is mainly used in the therapy of high blood pressure (hypertension) and diabetic nephropathy. it functions by relaxing blood vessels so that blood can flow more easily. it is also effective to help protect the kidneys from damage caused by diabetes and lower the risks of stroke in patients suffering from hypertension and myocardial enlargement. besides, recent study has suggested that losartan is beneficial to reverse age related dysfunction in maintaining normal blood pressure and cellular energy usage on mitochondria and it can probably be used to treat left ventricular hypertrophy. it may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure. |
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