high quality Letrozole CAS NO.112809-51-5

FOB Price:: USD 1.00-1.00 /Kilogram Get Latest Price

Min.Order Quantity:: 1 Kilogram

Purity:: 99%

Port:: China main port

Payment Terms:: L/C,T/T,

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Product Details

Keywords

Letrozole
high purity Letrozole
factory supply Letrozole

Quick Details

ProName: high quality Letrozole
CasNo: 112809-51-5
Molecular Formula: C17H11N5
Appearance: white to slightly beige crystalline po...
Application: Pharmaceutical intermediates
DeliveryTime: in stock
PackAge: as you requested
Port: China main port
ProductionCapacity: 10 Gram/Day
Purity: 99%
Storage: Room temperature
Transportation: by sea
LimitNum: 1 Kilogram
Transportation: by courier

Superiority

our company was built in 2009 with an iso certificate.in the past 5 years, we have grown up as a famous fine chemicals supplier in china and we had established stable business relationships with samsung,lg,merck,thermo fisher scientific and so on.our main business covers the fields below:

1.noble metal catalysts (pt.pd...)

2.organic phosphine ligands (tert-butyl-phosphine.cyclohexyl-phosphine...)

3.oled intermediates (fluorene,carbazole,boric acid...)

4.customs synthesis

our advantage:

1. higest quality and good package

2.fast delivery

3.better payment term

4.fast response to customer within 6 hours

5.good business credit in europe ,us ,japan ,korea

anyway ,if you need any chemicals from china ,henan tianfu can help you

Details

cas:	112809-51-5
mf:	c17h11n5
mw:	285.3
einecs:
product categories:	anti-cancer;pharmaceutical material and intermeidates;active pharmaceutical ingredients;letrozole;antineoplastic;all inhibitors;anti-neoplastic;inhibitors;intermediates & fine chemicals;pharmaceuticals;api's;apis;antibiotics;aromatics;heterocycles;eloxatin;anti-cancer&immunity
mol file:	112809-51-5.mol

letrozole chemical properties

melting point	181-183°c
storage temp.	-20°c freezer
solubility	dmso: >50mg/ml
color	white to off-white
inchikey	hpjkciuczwxjdr-uhfffaoysa-n
cas database reference	112809-51-5(cas database reference)

safety information

hazard codes	xi
risk statements	36/37/38
safety statements	26-36
rtecs	di4957000
hazardous substances data	112809-51-5(hazardous substances data)

msds information

provider	language
4,4'-(1h-1,2,4-triazol-1-ylmethylene)bisbenzonitrile	english

letrozole usage and synthesis

indications and uses	letrozole is part of a new generation of highly selective aromatase inhibitors and is an artificially synthesized benzotriazole derivative. letrozole inhibits aromatase to lower estrogen levels, thus preventing estrogen from stimulating tumor growth. its in vivo activity is 150-250 times stronger than that of first generation aromatase inhibitor amarante. as it is highly selective, it will not impact glucocorticoid, mineralocorticoid and thyroid functions; even at high dosages, it will not have any inhibiting effects on adrenal corticosteroid secretion, giving it a high treatment index. letrozole has no latent toxicity towards any bodily systems and target organs, has no mutagenicity and carcinogenic effects, has minimal toxic side effects, is well-tolerated, and has stronger anticancer effects than other aromatase inhibitors and antiestrogen drugs. letrozole is suitable for advanced breast cancer postmenopausal patients who have not responded to estrogen-suppressing treatment and for early breast cancer treatment. it is used to treat postmenopausal patients with advanced breast cancer and serves as a second-line treatment to follow unsuccessful antiestrogen treatment. compared to the current standard tamoxifen treatment, letrozole can better prevent the risk of breast cancer recurrence.
side effects	randomized grouping studies have shown that daily oral ingestion of 2.5mg letrozole leads to a 33% rate of drug-related negative reactions, a percentage much lower than ag group’s 46%. negative reactions to letrozole are mostly mild or moderate, consisting mostly of nausea (2-9%), headache (0-7%), bone pain (4-10%), hot flashes (0-9%) and weight gain (2-8%). other uncommon side effects include constipation, diarrhea, itching, rash, joint pain, chest pain, abdominal pain, fatigue, insomnia, dizziness, edema, high blood pressure, arrhythmia, thrombosis, dyspnea, vaginal bleeding, etc.
description	letrozole (trade name: femara) is an orally active nonsteroidal aromatase inhibitor. as a competitive inhibitor of the aromatase, letrozole inhibits the conversion of androgens to estrogen (estrogen stimulates breast tissues and breast cancer reoccurrence) and gonadal steroidogenesis. it can be used for the treatment of breast cancer that is hormonally-responsive or has an unknown receptor status in postmenopausal women. besides this, letrozole also has some off-label use such as ovarian stimulation, pretreatment of termination of pregnancy, treatment of gynecomastia, treatment of endometriosis, and promoting spermatogenesis for male patients of nonobstructive azoospermia.
chemical properties	white to light yellow crystal
uses	a nonsteroidal aromatase inhibitor structurally related to fadrozole. antineoplastic
references	# #