top Flumethasone CAS NO.2135-17-3

FOB Price:: USD 1.00-1.00 /Gram Get Latest Price

Min.Order Quantity:: 1 Gram

Purity:: 99% min

Port:: China main port

Payment Terms:: L/C,T/T,

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Product Details

Keywords

Flumethasone
high purity Flumethasone
factory supply Flumethasone

Quick Details

ProName: top Flumethasone
CasNo: 2135-17-3
Molecular Formula: C22H28F2O5
Appearance: white to light yellow crystal powder
Application: Pharmaceutical intermediates
DeliveryTime: With about 7-10 days after receipt the...
PackAge: as you requested
Port: China main port
ProductionCapacity: 10 Kilogram/Day
Purity: 99% min
Storage: Room temperature
Transportation: by courier
LimitNum: 1 Gram
Transportation: by courier

Superiority

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1.noble metal catalysts (pt.pd...)

2.organic phosphine ligands (tert-butyl-phosphine.cyclohexyl-phosphine...)

3.oled intermediates (fluorene,carbazole,boric acid...)

4.customs synthesis

our advantage:

1. higest quality and good package

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Details

product name:	flumethasone
synonyms:	cortexilar;flucort;flumethasone;aniprime;6a,9a-difluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione;6a,9a-difluoro-16a-methylprednisolone;6a-fluoro-dexamethasone;6alpha,9alpha-difluoro-16alpha-methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
cas:	2135-17-3
mf:	c22h28f2o5
mw:	410.45
einecs:	218-370-9
product categories:	intermediates & fine chemicals;pharmaceuticals;steroids;steroid and hormone;flucort;hormone drugs
mol file:	2135-17-3.mol

flumethasone chemical properties

melting point	237-240°c
storage temp.	2-8°c
solubility	acetic acid: soluble10mg/ml
color	white
merck	14,4138
cas database reference	2135-17-3(cas database reference)

safety information

hazard codes	xn
risk statements	40
safety statements	22-36
wgk germany	3
rtecs	tu3832000

msds information

provider	language
sigmaaldrich	english

flumethasone usage and synthesis

description	flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. its mechanism of action is thought to inhibit arachidonic acids role in the biosynthesis of prostaglandins and leukotrienes. flumethasone is active when it is not bound to the plasma protein transcortin. the drug flumethasone can be used to treat a variety of skin conditions, such as contact dermatitis, bug bites and eczema.
uses	flumethasone is an anti-inflammatory glucocorticoid used in veterinary practice and used as an anti-inflammatory for a variety of animals. it is commonly investigated for its effectiveness in animals to combat inflammatory symptoms caused by pathogens and to better understand inflammatory mechanisms. it is also used as to investigate novel techniques that detect and quantify steroid compounds within muscles. for the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions. flumethasone is a corticosteroid for topical use, in combination with clioquinol for the treatment of otitis externa and otomycosis. flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity. flumethasone has been shown to exert anti-inflammtory effects by functioning as a glucocorticoid receptor agonist. stimulating this receptor promotes inhibition of phospholipase a2 activity. this enzyme catalyzes arachidonic acid into eicosanoids most of which stimulate anti-inflammation mechanisms.
application	flumethasone is a topical corticosteroid of the glucocorticoid class used in the treatment of skin disorders where it reduces inflammation. flumethasone is insoluble in water. flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. a prompt decrease in inflammation, exudation and itching is experienced after application. it is commonly used in veterinary practice and has been used in cortisol assays to study early porcine conceptus development.
biological activity	flumethasone pivalate is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. it binds to the nucleus causing a variety of genetic activations and repressions. the anti-inflammatory action of flumethasone is thought to involve lipocortins and phospholipase a2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
chemical properties	white solid
uses	topical anti-inflammatory corticosteroid
uses	a glucocorticoid. an anti-inflammatory