1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment.
Response	P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Refer for medical attention. See Notes.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention . See Notes.

4.2 Most important symptoms/effects, acute and delayed

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Miosis, blurred vision; sweating, salivation; abdominal cramps, nausea, diarrhea, vomiting; headache, lassitude (weakness, exhaustion), muscle twitching Target Organs: central nervous system, liver, kidneys, gastrointestinal tract, blood cholinesterase (NIOSH, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

... Container identification is important to determine appropriate therapeutic measures, since the vehicle (eg, hydrocarbon, methanol) may be as toxic as the insecticide. ...

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers ... If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position ... The only respirators recommended for fire fighting are self-contained breathing apparatuses that have full facepieces and are operated in a pressure-demand or other positive-pressure mode.

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Evacuate persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after cleanup is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Keep in a well-ventilated room.Store in original container, preferably in locked area, away from children, food, feed.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.5 mg/cu m.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Hydrolized by strong alkali; 50% loss @ 20°C in 40 min @ pH 10

10.3 Possibility of hazardous reactions

PROPOXUR is incompatible with the following: Strong oxidizers, alkalis [Note: Emits highly toxic methyl isocyanate fumes when heated to decomposition.] (NIOSH, 2016).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Believed compatible with most insecticides, fungicides, except alkalines.

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /nitrogen oxide/.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat acute oral 95 to 104 mg/kg
• Inhalation: LC50 Rat inhalation >0.5 mg/L/4 hr (aerosol); >0.654 mg/L air/4 hr (dust)
• Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Group B2 Probable Human Carcinogen

Reproductive toxicity

No information is available on the reproductive or developmental effects of propoxur in humans. No adverse reproductive or developmental effects were observed in an oral study of rabbits exposed to propoxur. In a few studies of rats orally exposed to propoxur, fetotoxic effects, decreased numbers of pups, and depressed fetal weight have been reported.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow); Conditions: flow-through bioassay with measured concentrations, 22.5°C, dissolved oxygen 7.5 mg/L, hardness 45.4 mg/L CaCO3, alkalinity 40.0 mg/L CaCO3, pH 7.6; Concentration: 8.8 mg/L for 96 hr (confidence limit 7.4 - 10.5 mg/L)
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Conditions: freshwater, static; Concentration: 11 ug/L for 48 hr (95% confidence interval: 9-12 ug/L); Effect: intoxication, immobilization /98.8% purity
• Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green algae); Conditions: freshwater, static, 24°C; Concentration: 2848.4 ug/L for 96 hr; Effect: decreased population biomass /95% purity
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: The primary mode of biodegradation for propoxur appears to be hydrolysis of the carbamate linkage(1). The biodegradation of propoxur under aerobic conditions in silt loam and sandy loam soils followed first order kinetics for the first 112 and 180 days, respectively(1). The half-life values were 80 days for the silt loam and 210 days for the sandy loam(1). Propoxur was the major extractable residue found in the studies(1). One day after propoxur was applied to a sandy loam soil with no history of insecticidal treatment, 94% remained(2). However, when soil was previously treated four times with carbofuran (a methylcarbamate), only 20% of the propoxur remained after 1 day; this shows that acclimation markedly affects the rate of biodegradation of propoxur in soil(2). In another laboratory study, the biodegradation half-life of propoxur in Montardon soil, not previously treated with carbofuran, was 146 days, while in previously treated soil, the half-life was 9.3 days(3). Propoxur is reported to biodegrade quite rapidly in water, particularly when the bacterial activity and temperature are high(4). In a biodegradation test which used a combination of activated sludge, silt loam soil, and sediment as an inoculum, the half-life of propoxur was 44 days under aerobic conditions(5). When glucose and peptone was added as a source of carbon and energy, the half-life decreased to 19 days under aerobic conditions(5). Using a mixture of non-acclimated sludge, field soil, and river sediment as inoculum, the aerobic biodegradation half-life was 0.6 day at an initial concentration of 2 ppm at 18-22°C(6).

12.3 Bioaccumulative potential

An estimated BCF of 5 was calculated in fish for propoxur(SRC), using log Kow of 1.52(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of propoxur ranges from <1 to 103(1,2). In batch equilibrium studies, propoxur was very mobile, with Koc values of 3.4, 11.2, and 102.6 for sandy loam, silt loam, and silty clay soils, respectively(2). In other studies, Koc values ranged from 28-68, and for silt loam, sandy loam, sand, and clay loam soils, the Koc values were 39 (Kd = 0.597, 2.9 %OM, pH 5.9), 0.76 (Kd = 0.004, 1.1 %OM, pH 6.6), 34 (Kd = 0.181, 1.0 %OM, pH 4.3), and 28 (Kd = 0.329, 2.2 %OM, pH 6.4), respectively(1). According to a classification scheme(3), these Koc values suggest that propoxur has very high to high mobility in soil(SRC). In soil thin-layer mobility studies on six soils, propoxur was found to be mobile, with Rf values of 0.70 to 0.89(2).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.