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3,3'-Dichlorobenzidine SDS

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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,3'-Dichlorobenzidine

1.2 Other means of identification

Product number -
Other names 4-(4-amino-3-chlorophenyl)-2-chloroaniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. 3,3-Dichlorobenzidine is no longer used to manufacture dyes in the United States. In the past, it as used in the manufacture of pigments for printing ink, textiles, plastics, and crayons and as a curing agent for solid urethane plastics. (7) It is not used in commonplace consumer products.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Dermal, Category 4

Skin sensitization, Category 1

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H312 Harmful in contact with skin

H317 May cause an allergic skin reaction

H350 May cause cancer

H410 Very toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P273 Avoid release to the environment.

Response

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P391 Collect spillage.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
3,3'-Dichlorobenzidine 3,3'-Dichlorobenzidine 91-94-1 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Seek medical attention if you feel unwell.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Seek medical attention if you feel unwell.

In case of eye contact

Rinse with plenty of water (remove contact lenses if easily possible).

If swallowed

Rinse mouth. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Skin sensitization, dermatitis; headache, dizziness; caustic burns; frequent urination, dysuria; hematuria (blood in the urine); gastrointestinal upset; upper respiratory infection; [Potential occupational carcinogen] Target Organs: Bladder, liver, lung, skin, gastrointestinal tract Cancer Site [in animals: liver & bladder cancer] (NIOSH, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aniline and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Wear self contained breathing apparatus for fire fighting if necessary.

5.2 Specific hazards arising from the chemical

Combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Use of sodium hypochlorite bleach solution to decontaminate 3,3'-dichlorobenzidine was partially effective. An aqueous solution of 5% tetrapotassium pyrophosphate and 10% sodium ethyl hexyl sulfate when blended in a jet sprayer effectively removed 3,3'-dichlorobenzidine from a worker area (90-99% reduction). Once removed from the work site and collected in a central location, it was then determined that the diazotization reaction (the addition of sulfate, ice and sodium nitrate occurred to eliminate any detectable dichlorobenzine from the washings.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed. Store only in original container. Store in an area without drain or sewer access.Stable under recommended storage conditions.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers 3,3'-dichlorobenzidine (and its salts) to be a potential occupational carcinogens.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Gray to purple crystalline powder.
Colour Needles from alcohol or benzene
Odour no data available
Melting point/ freezing point 133oC
Boiling point or initial boiling point and boiling range 368oC
Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 10oC
Auto-ignition temperature 350°C
Decomposition temperature no data available
pH Weak base
Kinematic viscosity no data available
Solubility 0.07 % at 15°C (NIOSH, 2016)
Partition coefficient n-octanol/water (log value) log Kow = 3.51
Vapour pressure 4.1X10-6 mm Hg at 25°C (est)
Density and/or relative density 1.381g/cm3
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

A halide- and amine-substituted aromatic compound. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong oxidizing agents

10.6 Hazardous decomposition products

When heated to decomposition it emits very high toxic fumes of /hydrogen chloride and nitrogen oxides./

11.Toxicological information

Acute toxicity

  • Oral: LD50 Mouse (female) oral 352 mg/kg/day (7 consecutive days)
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

NTP: Reasonably anticipated to be a human carcinogen

Reproductive toxicity

No information is available on the reproductive or developmental effects of 3,3'-dichlorobenzidine in humans. Animal studies have reported abnormal growth in the kidneys of the fetuses of pregnant mice treated subcutaneously with 3,3'-dichlorobenzidine. No data were reported on maternal effects.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Pimephales promelas (Fathead Minnow) age 30 days, length 20 mm, weight 0.103 g; Conditions: freshwater, flow through, 22 (21.7-22.5)°C, pH 7.24 (6.76-7.54), hardness 51.6 (50.9-51.9) mg/L CaCO3, alkalinity 43 (36-46) mg/L CaCO3, dissolved oxygen 83.1% (73.7-88.5%); Concentration: 2080 ug/L for 96 hr /98% purity
  • Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water Flea) age <24 hr neonate; Conditions: freshwater, renewal, 22.3. (22-22.6°C), pH 8.43 (8.33-8.61), hardness 170 (163-183) mg/L CaCO3, alkalinity 108 (88-131) mg/L CaCO3, dissolved oxygen 98.4% (94.8-100.8%); Concentration: 1050 ug/L for 48 hr (95% confidence interval: 810-1360 ug/L) /98% purity
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

3,3-Dichlorobenzidine, present at 3 mg/L dissolved organic carbon, was 9-43% 0-91%, 34-93% and 18-99% biodegraded in 4 weeks using an activated sludge inoculum, amended with a yeast extract nutrient broth of 50, 100, 200 and 400 mg/L, respectively, in the Modified AFNOR test. No biodegradation was observed in tests not amended with the yeast extract(1). When incubated with natural aquatic communities from eutrophic and mesotrophic lakes, 25% of the 3,3'-dichlorobenzidine degraded in a month(2). When incubated in soil under aerobic conditions, only 2% mineralization occurred in 32 weeks and no degradation intermediates were detected(3). Under anaerobic conditions no mineralization occurred in a year(3). 3,3'-Dichlorobenzidine, present at 100 mg/L, achieved 1% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test which classified the compound as not readily biodegradable(4). The half-life of 3,3'-dichlorobenzidine in a lake water and sediment slurry obtained from Lake Macatawa, MI was approximately 150 days(5). 3,3'-Dichlorobenzidine dihydrochloride was not readily biodegradable by microorganisms obtained from freshwater lakes and incubated for 28 and 30 days or in an activated sludge study(6,7). These data suggest that biodegradation of 3,3'-dichlorobenzidine will occur slowly in the environment(SRC). Half-lives of 4-26 weeks and 16-101 weeks have been estimated for the biodegradation of 3,3'-dichlorobenzidine in surface water and anaerobic groundwater, respectively(8).

12.3 Bioaccumulative potential

The equilibrium bioconcentration factors using (14)-C-3,3'-dichlorobenzidine in whole bluegill sunfish (Lepomis macrochirus) was reported as 495-507, the BCF was 114-175 in the edible portion and 814-856 in non-edible parts(1). The BCF values measured in Golden ide fish (Leuciscus idus) and in algae were 610 and 940, respectively(2). A BCF range of 43-213 was measured in fish for 3,3'-dichlorobenzidine(SRC), using carp (Cyprinus carpio) which were exposed over an 8-week period(3). According to a classification scheme(4), these BCF data suggest the potential for bioconcentration in aquatic organisms is moderate to high(SRC).

12.4 Mobility in soil

Based upon measured Freundlich adsorption coefficients in a Brookston clay loam soil and a Rubicon sandy soil(1), the Koc of 3,3'-dichlorobenzidine can be determined to be 33,720 and 15,885 in the respective soils(SRC). Batch isotherm studies using five sandy to silty-clay sediment samples collected from Lake Macatawa (Holland, MI), measured Koc values ranging from 721 to 3,965(2); the majority of adsorption was determined to occur through covalent bonding(2). According to a classification scheme(3), these Koc values suggest that 3,3'-dichlorobenzidine is expected to have low to no mobility in soil. 3,3'-Dichlorobenzidine is a weak base with pKa values of 3.2 and 1.6(4), indicating that this compound will exist primarily in the neutral form. Aromatic amines like benzidine, 3,3'-dichlorobenzidine and substituted anilines are known to bind to soils containing a large organic carbon content due to the ability of the aromatic amino group to form covalent bonds with humic and fulvic material in soils(5). These complexes are often irreversibly bound and immobile(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN3077 IMDG: UN3077 IATA: UN3077

14.2 UN Proper Shipping Name

ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.

14.3 Transport hazard class(es)

ADR/RID: 9 IMDG: 9 IATA: 9

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
3,3'-Dichlorobenzidine 3,3'-Dichlorobenzidine 91-94-1 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 17, 2017
Revision Date Aug 17, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
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