1093878-42-2Relevant articles and documents
PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS
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Page/Page column 181-182, (2021/06/26)
The present application provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof; method for manufacturing said compound, and its therapeutic uses. The present application further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
CATHEPSIN CYSTEINE PROTEASE INHIBITORS
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Page/Page column 53, (2015/04/28)
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
CATHEPSIN CYSTEINE PROTEASE INHIBITORS
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Page/Page column 47, (2015/04/28)
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
CATHEPSIN CYSTEINE PROTEASE INHIBITORS
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Page/Page column 48-49, (2015/09/22)
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is i
Boric acid/glycerol as an efficient catalyst for synthesis of thiomorpholine 1,1-dioxide by double michael addition reaction in water
Halimehjnai, Azim Ziyaei,Hosseyni, Seyedmorteza,Gholami, Hadi,Hashemi, Mohammed M.
, p. 191 - 197,7 (2020/09/02)
Thiomorpholine 1,1-dioxides were prepared with double Michael addition reaction of aromatic amines to divinyl sulfone catalyzed by boric acid/glycerol in water. This catalyst system was also used for the Michael addition reaction of aromatic amines to electron-deficient alkenes. The reaction is simple and green and gives good to excellent yields.
COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS
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Page/Page column 91, (2011/02/24)
Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.
One-pot aryl-1,4-thiomorpholine 1,1-dioxide synthesis via double 1,4-addition of in situ reduced nitroarenes to divinyl sulfones
Han, Joon Hee,Choi, Jaehwan,Jun, Young Moo,Lee, Byung Min,Kim, Byeong Hyo
experimental part, p. 317 - 327 (2010/08/20)
One-pot reduction-triggered double aza-Michael type 1,4-addition reactions of various nitroarenes to divinyl sulfones were investigated. In the presence of indium/AcOH in MeOH or in sat. aq NH4Cl/MeOH, nitroarenes and divinyl sulfones were cycl
INHIBITORS OF JANUS KINASES
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Page/Page column 93, (2009/01/23)
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
