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CAS

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1191616-45-1

4-(4-bromo-phenyl)-1-methyl-1H-pyrazole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1191616-45-1 Structure

  • Basic information

    1. Product Name: 4-(4-bromo-phenyl)-1-methyl-1H-pyrazole
    2. Synonyms: 4-(4-bromo-phenyl)-1-methyl-1H-pyrazole
    3. CAS NO:1191616-45-1
    4. Molecular Formula:
    5. Molecular Weight: 237.099
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1191616-45-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 345.3±25.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: 1.44±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(4-bromo-phenyl)-1-methyl-1H-pyrazole(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(4-bromo-phenyl)-1-methyl-1H-pyrazole(1191616-45-1)
    11. EPA Substance Registry System: 4-(4-bromo-phenyl)-1-methyl-1H-pyrazole(1191616-45-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1191616-45-1(Hazardous Substances Data)

1191616-45-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1191616-45-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,1,6,1 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1191616-45:
(9*1)+(8*1)+(7*9)+(6*1)+(5*6)+(4*1)+(3*6)+(2*4)+(1*5)=151
151 % 10 = 1
So 1191616-45-1 is a valid CAS Registry Number.

1191616-45-1Downstream Products

1191616-45-1Relevant articles and documents

Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors

Yang, Bowen,Wu, Qian,Huan, Xiajuan,Wang, Yingqing,Sun, Yin,Yang, Yueyue,Liu, Tongchao,Wang, Xin,Chen, Lin,Xiong, Bing,Zhao, Dongmei,Miao, Zehong,Chen, Danqi

supporting information, (2020/12/28)

In an in-house screening, 1H-pyrrolo[2,3-b]pyridine scaffold was found to have high inhibition on TNIK. Several series of compounds were designed and synthesized, among which some compounds had potent TNIK inhibition with IC50 values lower than 1 nM. Some compounds showed concentration-dependent characteristics of IL-2 inhibition. These results provided new applications of TNIK inhibitors and new prospects of TNIK as a drug target.

NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS

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Paragraph 0161; 0170, (2020/07/07)

The present invention relates to novel compounds of formula (I): or a pharmaceutically acceptable salt or stereoisomer thereof, which exhibit the properties of a CDK 8/19 inhibitor. The invention also relates to a pharmaceutical composition containing said compounds and to the use thereof as pharmaceutical drugs for treating diseases or disorders.

HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE

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Page/Page column 261, (2019/08/12)

This invention relates to novel compounds and pharmaceutical compositions comprising. Compounds of the invention useful as modulators of Rho-associated protein kinase (ROCK), for example ROCK1 and/or ROCK2 inhibitors. Methods of treatment employing the compounds are also contemplated by the present invention. The compounds of the invention are useful in treating ROCK mediated diseases.

SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES

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Page/Page column 69, (2016/04/09)

The present invention relates to substituted indazoles and related heterocycles. These compounds are useful for the prevention and/or treatment of hyperproliferative, inflammatory and degenerative disorders and diseases. Thus, this invention is also concerned with the use of the compounds of the present invention for the the prevention and/or treatment of hyperproliferative, inflammatory and degenerative disorders and diseases as well as pharmaceutical composition, medicaments and kits comprising the substituted indazoles and related heterocycles of the present invention and processes for manufacturing those compounds.

Efficient synthesis of 4-substituted pyrazole via microwave-promoted Suzuki cross-coupling reaction

Cheng, Hua,Wu, Qiong-You,Han, Fan,Yang, Guang-Fu

, p. 705 - 709 (2014/06/09)

Pyrazoles and their derivatives are important heterocycles found in nature and present in numerous bioactive compounds. In contrast to 3 or 5-aryl pyrazole, the preparation of 4-aryl pyrazole is fairly rare. Utilizing microwave irradiation, the synthesis of 4-substituted-arylpyrazole via Suzuki cross-coupling has been developed with a wide range of substrates. The remarkable advantages of this method are mild reaction conditions, simple operation, high yield, and short reaction time. Product structures were identified by MS, 1H NMR, 13C NMR, and elemental analysis.

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