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1211539-82-0

2,2-Difluoro-1,3-benzodioxol-5-ol is an organic compound characterized by the presence of a benzodioxole ring with a hydroxyl group at the 5-position and two fluorine atoms at the 2-position. This unique structure endows it with specific chemical properties that make it a valuable intermediate in the synthesis of various pharmaceutical compounds.

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  • 1211539-82-0 Structure

  • Basic information

    1. Product Name: 2,2-Difluoro-1,3-benzodioxol-5-ol
    2. Synonyms: 2,2-Difluoro-1,3-benzodioxol-5-ol;2,2-difluorobenzo[d][1,3]dioxol-5-ol
    3. CAS NO:1211539-82-0
    4. Molecular Formula: C7H4F2O3
    5. Molecular Weight: 174.1016664
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1211539-82-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 2,2-Difluoro-1,3-benzodioxol-5-ol(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2,2-Difluoro-1,3-benzodioxol-5-ol(1211539-82-0)
    11. EPA Substance Registry System: 2,2-Difluoro-1,3-benzodioxol-5-ol(1211539-82-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1211539-82-0(Hazardous Substances Data)

1211539-82-0 Usage

Uses

Used in Pharmaceutical Industry:
2,2-Difluoro-1,3-benzodioxol-5-ol is used as a key intermediate in the synthesis of isobenzofuro[6,5-f][1,3]benzodioxolones. These compounds serve as small molecule inhibitors of the insulin-like growth factor-1 receptor (IGF-1R), which plays a crucial role in cell growth, proliferation, and survival. By targeting IGF-1R, these inhibitors can potentially be used in the treatment of various cancers and other diseases characterized by abnormal cell growth.

Check Digit Verification of cas no

The CAS Registry Mumber 1211539-82-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,1,5,3 and 9 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1211539-82:
(9*1)+(8*2)+(7*1)+(6*1)+(5*5)+(4*3)+(3*9)+(2*8)+(1*2)=120
120 % 10 = 0
So 1211539-82-0 is a valid CAS Registry Number.

1211539-82-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2-Difluoro-1,3-benzodioxol-5-ol

1.2 Other means of identification

Product number -
Other names 1,1'-Biphenyl,2,2'-difluoro-5,5'-dimethyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1211539-82-0 SDS

1211539-82-0Downstream Products

1211539-82-0Relevant articles and documents

2-(aryl (azacycloalkane-1-yl) methyl) phenol derivatives and uses thereof

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Paragraph 0350-0354, (2021/07/24)

The invention discloses 2-(aryl (azacycloalkane-1-yl) methyl) phenol derivatives and application thereof, and belongs to the technical field of medicines. The invention provides a compound shown in a formula I or pharmaceutically acceptable salt thereof. The series of compounds have good inhibitory activity on the histone demethylase KDM4 family in vitro, the median inhibitory concentration (IC50) of most molecules on KDM4D is less than 500 nM, and the compounds have good inhibitory effect on proliferation of various human tumor cell strains in vitro, so that the series of compounds provide a new effective choice for developing targeted histone demethylase KDM4D drugs and preparing drugs for treating and/or preventing cancers and reproductive system diseases, and have good application prospects.

SUBSTITUTED-N-HETEROARYL COMPOUNDS AND USES THEREOF

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Page/Page column 103, (2020/01/24)

The present disclosure relates generally to compounds useful for the treatment and/or enhancement of cognitive function and negative symptoms associated with central nervous system disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

SUBSTITUTED-PYRIDINYL COMPOUNDS AND USES THEREOF

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Page/Page column 44, (2020/01/10)

The present application relates generally to compounds useful for the treatment and/or enhancement of cognitive dysfunction and negative symptoms associated with CNS disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

MODULATORS OF THE INTEGRATED STRESS PATHWAY

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Page/Page column 316; 317; 342, (2019/05/22)

Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

MODULATORS OF THE INTEGRATED STRESS PATHWAY

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Page/Page column 133, (2019/05/22)

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

MODULATORS OF THE INTEGRATED STRESS PATHWAY

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Page/Page column 297-298, (2019/05/22)

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

MODULATORS OF THE INTEGRATED STRESS PATHWAY

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Page/Page column 224, (2019/05/22)

Provided herein are compounds of formula (I) and (II), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use

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Paragraph 0958, (2018/09/16)

The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the inventi

HEMOGLOBIN MODIFIER COMPOUNDS AND USES THEREOF

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Paragraph 00407, (2018/02/28)

Described herein are compounds, including pharmaceutically acceptable salts thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat, prevent or diagnose blood-based diseases, disorders or conditions.

SUBSTITUTED TRICYCLICS AND METHOD OF USE

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Paragraph 0951, (2017/02/09)

The present invention provides for compounds of formula (I) wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sj?gren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

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