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Tert-butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate, commonly known as carbetapentane, is a carboxylic acid ester compound with a unique chemical structure that features a tert-butyl group, a benzyl group, and a 2,6-diazaspiro[3.4]octane ring. These structural elements contribute to its pharmacological properties, making it a potent centrally acting cough suppressant.

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  • 1352926-14-7 Structure
  • Basic information

    1. Product Name: Tert-butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate
    2. Synonyms: Tert-butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate;Tert-Butyl 6-Benzyl-2,6-Diazaspiro[3.4]Octane-2-Carboxylate(WX101041)
    3. CAS NO:1352926-14-7
    4. Molecular Formula: C18H26N2O2
    5. Molecular Weight: 302.41124
    6. EINECS: 200-258-5
    7. Product Categories: N/A
    8. Mol File: 1352926-14-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 398.2±35.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.13±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 8.95±0.20(Predicted)
    10. CAS DataBase Reference: Tert-butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: Tert-butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate(1352926-14-7)
    12. EPA Substance Registry System: Tert-butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate(1352926-14-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1352926-14-7(Hazardous Substances Data)

1352926-14-7 Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate is used as a centrally acting cough suppressant for treating coughs. It works by affecting the cough center in the brain, reducing the urge to cough and providing relief from coughing.
Tert-butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate is used as an active ingredient in over-the-counter cough and cold medications. It is often found either as a standalone component or in combination with other drugs to enhance their effectiveness in treating cough and cold symptoms.

Check Digit Verification of cas no

The CAS Registry Mumber 1352926-14-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,2,9,2 and 6 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1352926-14:
(9*1)+(8*3)+(7*5)+(6*2)+(5*9)+(4*2)+(3*6)+(2*1)+(1*4)=157
157 % 10 = 7
So 1352926-14-7 is a valid CAS Registry Number.

1352926-14-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-Butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate

1.2 Other means of identification

Product number -
Other names tert-butyl 7-benzyl-2,7-diazaspiro[3.4]octane-2-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1352926-14-7 SDS

1352926-14-7Downstream Products

1352926-14-7Relevant articles and documents

ADAMANTANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION

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Paragraph 0886-0888, (2020/02/05)

Compounds of structural Formula I were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus, wherein, R1, R2, R3, X and Y are defined in the specification.

ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION

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Page/Page column 85; 86, (2017/09/02)

Compounds of structural Formula (I) were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus.

Synthesis of Orthogonally Protected 2,6-Diazaspiro[35]nonane and 2,6-Diazaspiro[3.4]octane Analogues as Versatile Building Blocks in Medicinal Chemistry

Orain, David,Hintermann, Samuel,Pudelko, Maciej,Carballa, Diego,Jedrzejczak, Anna

, p. 1815 - 1818 (2015/08/06)

A novel and efficient synthesis of orthogonally protected spirocyclic amines is described for the first time.

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