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1379324-48-7

2-(5-bromo-2-fluorophenyl)-1H-imidazole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1379324-48-7 Structure

  • Basic information

    1. Product Name: 2-(5-bromo-2-fluorophenyl)-1H-imidazole
    2. Synonyms:
    3. CAS NO:1379324-48-7
    4. Molecular Formula:
    5. Molecular Weight: 241.062
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1379324-48-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(5-bromo-2-fluorophenyl)-1H-imidazole(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(5-bromo-2-fluorophenyl)-1H-imidazole(1379324-48-7)
    11. EPA Substance Registry System: 2-(5-bromo-2-fluorophenyl)-1H-imidazole(1379324-48-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1379324-48-7(Hazardous Substances Data)

1379324-48-7 Usage

Type of compound

Imidazole derivative

Structure

Five-membered heterocyclic ring containing two nitrogen atoms

Appearance

White solid

Usage

Commonly used in pharmaceutical research and drug development

Biological activities

Antifungal, antibacterial, and anticancer properties

Influence of halogens

Presence of bromine and fluorine atoms in the phenyl ring may contribute to specific biological activities and targeted interactions with biological molecules

Versatility

Potential applications in various fields of research and industry

Check Digit Verification of cas no

The CAS Registry Mumber 1379324-48-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,9,3,2 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1379324-48:
(9*1)+(8*3)+(7*7)+(6*9)+(5*3)+(4*2)+(3*4)+(2*4)+(1*8)=187
187 % 10 = 7
So 1379324-48-7 is a valid CAS Registry Number.

1379324-48-7Downstream Products

1379324-48-7Relevant articles and documents

INHIBITOR CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

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Paragraph 0113; 0164-0168, (2021/04/16)

An inhibitor containing a tricyclic derivative, a preparation method therefor and a pharmaceutical composition comprising the inhibitor, as well as a use thereof as a phosphoinositide 3 kinase (PI3K) inhibitor in the treatment of cancer and diseases or conditions mediated by or dependent on PI3K imbalance.

Crystal form containing triple-fused-ring derivative free alkali and pharmaceutical composition thereof

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Paragraph 0744-0751, (2021/05/26)

The invention relates to a crystal form containing triple-fused-ring derivative free alkali and a pharmaceutical composition thereof. The invention specifically relates to a crystal form of a compound free alkali with a general formula (I), a preparation method, a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and an application of the crystal form in preparation of drugs for treating PI3K-mediated related diseases.

Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K)

Castanedo, Georgette M.,Blaquiere, Nicole,Beresini, Maureen,Bravo, Brandon,Brightbill, Hans,Chen, Jacob,Cui, Hai-Feng,Eigenbrot, Charles,Everett, Christine,Feng, Jianwen,Godemann, Robert,Gogol, Emily,Hymowitz, Sarah,Johnson, Adam,Kayagaki, Nobuhiko,Kohli, Pawan Bir,Knüppel, Kathleen,Kraemer, Joachim,Krüger, Susan,Loke, Pui,McEwan, Paul,Montalbetti, Christian,Roberts, David A.,Smith, Myron,Steinbacher, Stefan,Sujatha-Bhaskar, Swathi,Takahashi, Ryan,Wang, Xiaolu,Wu, Lawren C.,Zhang, Yamin,Staben, Steven T.

supporting information, p. 627 - 640 (2017/02/05)

We report here structure-guided optimization of a novel series of NF-κB inducing kinase (NIK) inhibitors. Starting from a modestly potent, low molecular weight lead, activity was improved by designing a type 11/2 binding mode that accessed a back pocket past the methionine-471 gatekeeper. Divergent binding modes in NIK and PI3K were exploited to dampen PI3K inhibition while maintaining NIK inhibition within these series. Potent compounds were discovered that selectively inhibit the nuclear translocation of NF-κB2 (p52/REL-B) but not canonical NF-κB1 (REL-A/p50).

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