141761-85-5 Usage
Uses
Used in Pharmaceutical Synthesis:
Methyl 6-bromo-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate is used as a building block in the pharmaceutical industry for the synthesis of various organic compounds. Its unique structure, including the bromine atom and functional groups, makes it a promising candidate for the development of new drugs and pharmaceutical agents.
Used in Chemical Research:
In the field of chemical research, Methyl 6-bromo-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate may be utilized for studying its chemical properties and potential reactions with other compounds. This can contribute to the advancement of organic chemistry and the discovery of new chemical processes or applications.
Used in Industrial Processes:
Methyl 6-bromo-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylate may also find use in various industrial processes, where its unique structure and properties could be leveraged for specific applications. These could include the development of new materials, catalysts, or other chemical intermediates that require the presence of a bromine atom and functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 141761-85-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,7,6 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 141761-85:
(8*1)+(7*4)+(6*1)+(5*7)+(4*6)+(3*1)+(2*8)+(1*5)=125
125 % 10 = 5
So 141761-85-5 is a valid CAS Registry Number.
141761-85-5Relevant articles and documents
Synthesis and pharmacology of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives, a new class of potent serotonin-3 (5-HT3) receptor antagonists
Kawakita,Kuroita,Yasumoto,Sano,Inaba,Fukuda,Tahara
, p. 624 - 630 (2007/10/02)
A series of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity assessed by their ability to antagonize the von Bezold-Jarish (BJ) effect in rats. Derivatives bearing 1-azabicyclo[2.2.2]oct-3-yl moiety as a basic function attached to the carboxamide at position 8 showed more potent antagonistic activity than those bearing the other three basic moieties. Structure activity relationships of this series showed that methyl and chloro groups were more effective as substituents at positions 4 and 6, respectively. The representative compound 15 (Y-25130) in this series showed potent antagonistic activity on the BJ effect (ED50 = 1.3 μg/kg i.v.), high affinity for 5-HT3 receptor (K(i) = 2.9 nM) and complete protection against cisplatin-induced emesis in dogs at a dose of 0.1 mg/kg i.v.
