141761-82-2

Basic information

• Product Name: Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+%
• Synonyms: Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+%;Methyl 3-amino-5-bromo-2-hydroxybenzenecarboxylate;2-Amino-4-bromo-6-(methoxycarbonyl)phenol, 5-Bromo-2-hydroxy-3-(methoxycarbonyl)aniline;Methyl 3-aMino-5-broMo-2-hydroxybenzoate;Methyl 3-amino-5-bromosalicylate, 2-Amino-4-bromo-6-(methoxycarbonyl)phenol, 5-Bromo-2-hydroxy-3-(methoxycarbonyl)aniline;3-amino-5-bromo-2-hydroxybenzoate
• CAS NO: 141761-82-2
• Molecular Formula: C₈H₈BrNO₃
• Molecular Weight: 246
• Mol File: 141761-82-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+%(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+%(141761-82-2)
• EPA Substance Registry System: Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+%(141761-82-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 141761-82-2(Hazardous Substances Data)

Usage

General Description

Methyl 3-amino-5-bromo-2-hydroxybenzoate is a chemical compound with a purity of 95% or higher. It is a derivative of benzoic acid with a methyl group, an amino group, and a bromine atom attached to the benzene ring, as well as a hydroxyl group at the 2-position. Methyl 3-amino-5-bromo-2-hydroxybenzoate 95+% is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It can also be used as a building block in the production of specialty chemicals and as a reagent in organic synthesis. Methyl 3-amino-5-bromo-2-hydroxybenzoate is a versatile chemical with a wide range of potential applications in various industries.

Upstream product

• 91983-31-2 methyl 5-bromo-2-hydroxy-3-nitrobenzoate 
• 67-56-1 methanol 
• 69-72-7 salicylic acid 
• 119-36-8 methyl salicylate 
• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 

Downstream Products

• 141761-88-8 6-Bromo-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid methyl ester 
• 141761-85-5 6-Bromo-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid methyl ester 

Relevant articles and documents

WDR5-MYC INHIBITORS

Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

Synthesis and pharmacology of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives, a new class of potent serotonin-3 (5-HT3) receptor antagonists

A series of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity assessed by their ability to antagonize the von Bezold-Jarish (BJ) effect in rats. Derivatives bearing 1-azabicyclo[2.2.2]oct-3-yl moiety as a basic function attached to the carboxamide at position 8 showed more potent antagonistic activity than those bearing the other three basic moieties. Structure activity relationships of this series showed that methyl and chloro groups were more effective as substituents at positions 4 and 6, respectively. The representative compound 15 (Y-25130) in this series showed potent antagonistic activity on the BJ effect (ED50 = 1.3 μg/kg i.v.), high affinity for 5-HT3 receptor (K(i) = 2.9 nM) and complete protection against cisplatin-induced emesis in dogs at a dose of 0.1 mg/kg i.v.