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1427452-48-9

7-chloro-[1,2,4]triazolo[1,5-a]pyridine, also known as 7-Cl-TRP, is a heterocyclic chemical compound with the molecular formula C5H3ClN4. It features a triazole ring fused to a pyridine ring, with a chlorine atom attached at the seventh position. 7-chloro-[1,2,4]triazolo[1,5-a]pyridine holds potential in the pharmaceutical industry for the development of new drugs and as a building block in organic synthesis for constructing more complex molecules. Additionally, 7-Cl-TRP may exhibit biological activity, making it a valuable research tool in pharmacological studies.

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  • 1427452-48-9 Structure

  • Basic information

    1. Product Name: 7-Chloro-[1,2,4]triazolo[1,5-a]pyridine
    2. Synonyms: 7-Chloro-[1,2,4]triazolo[1,5-a]pyridine
    3. CAS NO:1427452-48-9
    4. Molecular Formula: C6H4ClN3
    5. Molecular Weight: 153.56906
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1427452-48-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 7-Chloro-[1,2,4]triazolo[1,5-a]pyridine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 7-Chloro-[1,2,4]triazolo[1,5-a]pyridine(1427452-48-9)
    11. EPA Substance Registry System: 7-Chloro-[1,2,4]triazolo[1,5-a]pyridine(1427452-48-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1427452-48-9(Hazardous Substances Data)

1427452-48-9 Usage

Uses

Used in Pharmaceutical Industry:
7-chloro-[1,2,4]triazolo[1,5-a]pyridine is used as a potential drug candidate for the development of new pharmaceuticals due to its unique chemical structure and potential biological activity.
Used in Organic Synthesis:
7-Cl-TRP is used as a building block in organic synthesis for the construction of more complex molecules, contributing to the creation of novel compounds with diverse applications.
Used in Research and Development:
7-chloro-[1,2,4]triazolo[1,5-a]pyridine is used as a research tool in studies related to its pharmacological properties, aiding in the understanding of its potential therapeutic effects and mechanisms of action.

Check Digit Verification of cas no

The CAS Registry Mumber 1427452-48-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,7,4,5 and 2 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1427452-48:
(9*1)+(8*4)+(7*2)+(6*7)+(5*4)+(4*5)+(3*2)+(2*4)+(1*8)=159
159 % 10 = 9
So 1427452-48-9 is a valid CAS Registry Number.

1427452-48-9Relevant articles and documents

TRIAZOLOPYRIDINE COMPOUNDS USEFUL AS PESTICIDES

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Page/Page column 70-72, (2022/01/12)

The present disclosure provides a novel triazolopyridine compound as represented by formula (I) or a salt thereof that controls pests: wherein, R1 and R3 independently represent hydrogen, or the like; R2 represents C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, or the like; R4, R5, R7, and R8 independently represent hydrogen, halogen, or the like; R6 represents C1-C6 haloalkoxy, or the like; and Z represents an oxygen atom, a sulfur atom, SO, or SO2.

Preparation method of Tucatinib intermediate

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Paragraph 0015; 0029; 0033-0034; 0041-0045; 0052; ..., (2021/06/06)

The invention discloses a preparation method of a tucatinib intermediate, which comprises the following steps: firstly, reacting 4-chloropyrido-2-amine with N,N-dimethylformamide dimethyl acetal, and then adding hydroxylamine hydrochloride for reaction to

T3P-Mediated N-N Cyclization for the Synthesis of 1,2,4-Triazolo[1,5- a]pyridines

Ayothiraman, Rajaram,Bandaru, Durgarao,Paranthaman, Ranjitha,Fenster, Micha?l,Eastgate, Martin D.,Vaidyanathan, Rajappa

, p. 2510 - 2515 (2019/11/11)

Propylphosphonic anhydride has been shown to be an effective reagent for the synthesis of substituted [1,2,4]triazolo[1,5-a]pyridines from the corresponding N′-hydroxy-N-formimidamides. The reactions worked under mild conditions and exhibited wide functional group tolerance, delivering the triazolopyridines in good to excellent yields and purities.

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