1431411-66-3 Usage
Uses
Used in Pharmaceutical Industry:
Thieno[3,2-d]pyrimidine-6-carboxamide, 4-[4-[2-[(Methylsulfonyl)amino]ethyl]-1-piperidinyl]is used as a potential kinase inhibitor for the development of targeted therapies against various diseases, including cancer. Its structure allows for specific interactions with kinase enzymes, which play a crucial role in cellular signaling pathways and are often dysregulated in disease states.
Used in Anticancer Applications:
In the field of oncology, Thieno[3,2-d]pyrimidine-6-carboxamide, 4-[4-[2-[(Methylsulfonyl)amino]ethyl]-1-piperidinyl]is used as a potential antineoplastic agent. Its ability to inhibit kinases involved in cell proliferation and survival may contribute to the suppression of tumor growth and the prevention of cancer progression.
Used in Neurological Disorder Treatment:
Thieno[3,2-d]pyrimidine-6-carboxamide, 4-[4-[2-[(Methylsulfonyl)amino]ethyl]-1-piperidinyl]is used as a potential treatment for neurological disorders due to its interaction with neurotransmitter receptors. This interaction may help modulate neuronal signaling and alleviate symptoms associated with various neurological conditions.
Used in Drug Development Research:
In the research and development of new pharmaceuticals, Thieno[3,2-d]pyrimidine-6-carboxamide, 4-[4-[2-[(Methylsulfonyl)amino]ethyl]-1-piperidinyl]serves as a valuable compound for studying its structure-activity relationships and exploring its potential as a lead compound in the development of novel therapeutic agents for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1431411-66-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,3,1,4,1 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1431411-66:
(9*1)+(8*4)+(7*3)+(6*1)+(5*4)+(4*1)+(3*1)+(2*6)+(1*6)=113
113 % 10 = 3
So 1431411-66-3 is a valid CAS Registry Number.
1431411-66-3Relevant articles and documents
THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS
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Page/Page column 65; 127, (2014/09/29)
Provided herein are novel substituted thieno[3,2-d]pyrimidine-6-carboxamide sirtuin inhibitors and methods of use thereof. The sirtuin inhibitors may be used for inhibiting a sirtuin-mediated biological process, and, e.g. for treating and/or preventing diseases and disorders including, but not limited to cancer, neurodegenerative disease and inflammation. Also provided herein are pharmaceutical compositions comprising these sirtuin inhibitors and compositions comprising a sirtuin inhibitor in combination with another therapeutic agent.
Discovery of thieno[3,2-d ]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3
Disch, Jeremy S.,Evindar, Ghotas,Chiu, Cynthia H.,Blum, Charles A.,Dai, Han,Jin, Lei,Schuman, Eli,Lind, Kenneth E.,Belyanskaya, Svetlana L.,Deng, Jianghe,Coppo, Frank,Aquilani, Leah,Graybill, Todd L.,Cuozzo, John W.,Lavu, Siva,Mao, Cheney,Vlasuk, George P.,Perni, Robert B.
supporting information, p. 3666 - 3679 (2013/06/27)
The sirtuins SIRT1, SIRT2, and SIRT3 are NAD+ dependent deacetylases that are considered potential targets for metabolic, inflammatory, oncologic, and neurodegenerative disorders. Encoded library technology (ELT) was used to affinity screen a 1
