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1440526-64-6

4-Chloro-5-iodo-2-Methoxy-benzoic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1440526-64-6 Structure

  • Basic information

    1. Product Name: 4-Chloro-5-iodo-2-Methoxy-benzoic acid
    2. Synonyms: 4-Chloro-5-iodo-2-Methoxy-benzoic acid;Benzoic acid, 4-chloro-5-iodo-2-methoxy-
    3. CAS NO:1440526-64-6
    4. Molecular Formula: C8H6ClIO3
    5. Molecular Weight: 312.48891
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 1440526-64-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-Chloro-5-iodo-2-Methoxy-benzoic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-Chloro-5-iodo-2-Methoxy-benzoic acid(1440526-64-6)
    11. EPA Substance Registry System: 4-Chloro-5-iodo-2-Methoxy-benzoic acid(1440526-64-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1440526-64-6(Hazardous Substances Data)

1440526-64-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1440526-64-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,0,5,2 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1440526-64:
(9*1)+(8*4)+(7*4)+(6*0)+(5*5)+(4*2)+(3*6)+(2*6)+(1*4)=136
136 % 10 = 6
So 1440526-64-6 is a valid CAS Registry Number.

1440526-64-6Downstream Products

1440526-64-6Relevant articles and documents

Discovery of KRas G12C-IN-3 and Pomalidomide-based PROTACs as degraders of endogenous KRAS G12C with potent anticancer activity

Li, Ling,Wu, Yinrong,Yang, Zichao,Xu, Chenglong,Zhao, Huiting,Liu, Jin,Chen, Jingxuan,Chen, Jianjun

, (2021/10/29)

A series of KRAS G12C-targeting PROTACs (PROteolysis TArgeting Chimeras) were designed and synthesized based on KRas G12C-IN-3 (a KRAS G12C inhibitor) and pomalidomide as degraders of KRAS G12C with a molecular weight of 50≈1.25 μM). KP-14 bound to KRAS G12C through the acrylamide warhead and recruited the E3 ligase CRBN, causing rapid and sustained KRAS G12C degradation which led to suppression of MAPK signaling pathway in NCI-H358 cells. In addition, KP-14 selectively induced the degradation of KRAS G12C but not other KRAS isoforms such as G13D via PROTAC mechanism. Furthermore, KP-14 exhibited potent antiproliferative activity against NCI-H358 cancer cells and was able to suppress the formation of NCI-H358 tumor colonies. Collectively, this work suggests that KP-14 may serve as a tool compound for exploring the degradation of KRAS G12C by PROTAC strategy and deserve further investigation as a potential anticancer agent.

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