145373-80-4Relevant articles and documents
Synthesis and characterization of picket porphyrin receptors that bind phosphatidylglycerol, an anionic phospholipid found in bacterial membranes
Alliband, Amanda,Meece, Frederick A.,Jayasinghe, Champika,Burns, Dennis H.
, p. 356 - 362 (2013)
The lipid binding ability of four urea-picket porphyrins designed to bind to both the phosphate anion portion as well as the glycerol hydroxyl groups of phosphatidylglycerol (PG) has been investigated. Isothermal titration calorimetry (ITC) and 1H NMR were used to determine the receptor's stoichiometry of binding, association constants, and both the enthalpy and entropy of binding with the PG anion. Spectral evidence shows that the phosphate anion portion of PG is hydrogen bonded to the urea groups of the receptors. This binding interaction orients the PG anion in the receptor pocket such that its glycerol hydroxyl groups can align with a third urea picket, and results are furnished that suggest this multifunctional interaction does occur. The structure of the entire picket was found to influence the enthalpy and entropy of lipid binding. The synthesis of tetrabutlyammonium phosphatidylglycerol (TBAPG), and a detailed spectral characterization of its headgroup, is also presented.
Synthesis and characterization of a 3-hydroxy-4-pyridinone chelator functionalized with a polyethylene glycol (PEG) chain aimed at sequential injection determination of iron in natural waters
Mesquita, Raquel B.R.,Moniz, Tania,Miranda, Joana L.A.,Gomes, Vania,Silva, André M.N.,Rodriguez-Borges,Rangel, António O.S.S.,Rangel, Maria
, p. 171 - 178 (2015)
The synthesis of a highly water soluble 3-hydroxy-4-pyridinone ligand, functionalized with a hydrophilic ethylene glycol chain (PEG-HPO), was successfully achieved and is reported together with that of its iron(III) complex. The improved hydrophilicity of both the PEGylated 3,4-HPO ligand and its iron(III) complex were fully investigated in an analytical application and, the new chelator is proposed for the spectrophotometric sequential injection determination of iron in waters. The new ligand provided better sensitivity and a lower LOD for iron determination than that obtained for N-alkyl-3-hydroxy-4-pyridinone ligands. The developed sequential injection method presents a dynamic working range of 0.10-1.00 mg Fe/L with a LOD of 48 μg/L. Due to the use of a sequential injection system, the overall effluent production was 3, 0.92 mg of HNO3 and 500 μL of sample. Two reference samples were assessed for accuracy studies and a relative deviation 5% was obtained; eight waters samples were analyzed and the results compared with the reference procedure, and no statistical difference was observed for the two sets of results.
Deep-blue-emitting nanoaggregates from carbazole-based dyes in water
Li, Xiaohui,Zhang, Qi,Zhang, Xin
, p. 104 - 107 (2021/12/29)
New amphiphilic carbazole-based dyes assemble in water into deep-blue-emitting, highly fluorescent helical aggregates as observed by transmission electron microscopy and atomic force microscopy. Single crystal X-ray diffraction and NMR spectroscopy reveal
PYRROLO[2,3-B]PYRIDIN DERIVATIVES AS INHIBITORS OF INFLUENZA VIRUS REPLICATION
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, (2020/02/16)
Provided herein are compounds of Formula A, B or C that can inhibit the replication of influenza viruses, reduce the amount of influenza viruses, and/or treat influenza.
PYRROLOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF INFLUENZA VIRUS REPLICATION
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, (2018/11/22)
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient a safe and effective amount of a compound represented by any of Formulas l-lll, or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a safe and effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
A Synthesis of acetamidines
Harjani, Jitendra R.,Liang, Chen,Jessop, Philip G.
, p. 1683 - 1691 (2011/05/12)
The condensation of primary amine with N,N-dimethylacetamide dimethyl acetal yields amixture of acetamidine and imidate ester. The product distribution in this reaction depends on the temperature, solvent, and structure of the primary amine. It is possible to suppress the formation of imidate ester by performing the reaction in the presence of excess dimethyl amine, yielding acetamidine as the exclusive product. For acetamidines that cannot be purified either by crystallization or distillation, this new method is necessary for the generation of pure acetamidines in good yields.
