1454706-29-6Relevant articles and documents
Robustness, Entrainment, and Hybridization in Dissipative Molecular Networks, and the Origin of Life
Cafferty, Brian J.,Wong, Albert S. Y.,Semenov, Sergey N.,Belding, Lee,Gmür, Samira,Huck, Wilhelm T. S.,Whitesides, George M.
supporting information, p. 8289 - 8295 (2019/06/04)
How simple chemical reactions self-assembled into complex, robust networks at the origin of life is unknown. This general problem-self-assembly of dissipative molecular networks-is also important in understanding the growth of complexity from simplicity in molecular and biomolecular systems. Here, we describe how heterogeneity in the composition of a small network of oscillatory organic reactions can sustain (rather than stop) these oscillations, when homogeneity in their composition does not. Specifically, multiple reactants in an amide-forming network sustain oscillation when the environment (here, the space velocity) changes, while homogeneous networks-those with fewer reactants-do not. Remarkably, a mixture of two reactants of different structure-neither of which produces oscillations individually-oscillates when combined. These results demonstrate that molecular heterogeneity present in mixtures of reactants can promote rather than suppress complex behaviors.
Substituted amino acid thioester compound, its composition and application specifically related to preparing the drugs for treating virus infectious diseases
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Page/Page column 24; 25, (2017/10/26)
The present invention relates to a substituted amino acid thioester compound represented by the general formula (A), its composition and application, wherein the definitions of the substituents in the general formula (A) are the same as those defined in t
Preparation of peptide thioesters through fmoc-based solid-phase peptide synthesis by using amino thioesters
Stuhr-Hansen, Nicolai,Wilbek, Theis S.,Stromgaard, Kristian
supporting information, p. 5290 - 5294 (2013/09/02)
An effective procedure for the synthesis of peptide alkyl thioesters by 9-fluorenylmethoxycarbonyl (Fmoc) solid-phase peptide synthesis was developed. The free C terminus of a fully protected peptide was coupled in solution with the free amino group of an
