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CAS

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14678-95-6

5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE& is a pyrazole derivative with the molecular formula C10H10N4O. It features a substituted phenyl group and is utilized in pharmaceutical research as a building block for synthesizing various biologically active compounds. The 4-methoxyphenyl group attached to the pyrazole ring offers the potential to modulate the compound's properties and activities, making it a promising candidate for the development of new drugs or therapeutic agents.

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  • 14678-95-6 Structure

  • Basic information

    1. Product Name: 5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE&
    2. Synonyms: 5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE&;5-Amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid;5-Amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid 97%
    3. CAS NO:14678-95-6
    4. Molecular Formula: C11H11N3O3
    5. Molecular Weight: 233.23
    6. EINECS: N/A
    7. Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrazoles
    8. Mol File: 14678-95-6.mol

  • Chemical Properties

    1. Melting Point: 180-185 °C (dec.)(lit.)
    2. Boiling Point: 462.2 °C at 760 mmHg
    3. Flash Point: 233.4 °C
    4. Appearance: /
    5. Density: 1.41 g/cm3
    6. Vapor Pressure: 2.42E-09mmHg at 25°C
    7. Refractive Index: 1.646
    8. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: 4.50±0.10(Predicted)
    11. CAS DataBase Reference: 5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE&(CAS DataBase Reference)
    12. NIST Chemistry Reference: 5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE&(14678-95-6)
    13. EPA Substance Registry System: 5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE&(14678-95-6)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 43
    3. Safety Statements: 26-36/37
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 14678-95-6(Hazardous Substances Data)

14678-95-6 Usage

Uses

Used in Pharmaceutical Research:
5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE& is used as a building block for the synthesis of biologically active compounds in pharmaceutical research. Its unique structure and potential biological activity contribute to the development of new drugs or therapeutic agents.
Used in Drug Development:
In the Drug Development industry, 5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE& is used as a precursor for creating new drugs or therapeutic agents. 5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE&'s structure and the 4-methoxyphenyl group's ability to modulate properties and activities make it a valuable component in the formulation of innovative pharmaceuticals.
Further research and testing are necessary to fully understand the potential uses and implications of 5-amino-1-(4-methoxyphenyl)-1H-pyrazole, ensuring its safe and effective application in the pharmaceutical and drug development industries.

Check Digit Verification of cas no

The CAS Registry Mumber 14678-95-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,6,7 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14678-95:
(7*1)+(6*4)+(5*6)+(4*7)+(3*8)+(2*9)+(1*5)=136
136 % 10 = 6
So 14678-95-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H11N3O3/c1-17-8-4-2-7(3-5-8)14-10(12)9(6-13-14)11(15)16/h2-6H,12H2,1H3,(H,15,16)

14678-95-6 Well-known Company Product Price

  • Brand
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  • Aldrich

  • (639788)  5-Amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylicacid  97%

  • 14678-95-6

  • 639788-1G

  • 932.49CNY

  • Detail

14678-95-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14678-95-6 SDS

14678-95-6Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Ferreira, Byanca Silva,Silva, Rafaela Corrêa,Souto, Bernardo Araújo,Dos Santos, Maurício Silva

, p. 335 - 343 (2021/09/07)

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

Design, synthesis and biological evaluation of novel pyrazolo-pyrimidinones as DPP-IV inhibitors in diabetes

Sagar, Sneha R.,Agarwal, Jessica K.,Pandya, Dhaivat H.,Dash, Ranjeet Prasad,Nivsarkar, Manish,Vasu, Kamala K.

supporting information, p. 4428 - 4433 (2015/10/12)

We report the design, synthesis, biological activity and docking studies of series of novel pyrazolo[3,4-d]pyrimidinones as DPP-IV inhibitors in diabetes. Molecules were synthesized and evaluated for their DPP-IV inhibition activity. Compounds 5e, 5k, 5o and 6a were found to be potent inhibitors of DPP-IV enzyme. Amongst all the synthesized compounds, 6-methyl-5-(4-methylpyridin-2-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (5k) was found to be the most active based on in vitro DPP-IV studies and also exhibited promising in vivo blood glucose lowering activity in male Wistar rats.

3-AMINO-PYRAZOLE-4-CARBOXAMIDE DERIVATIVES USEFUL AS INHIBITORS OF PROTEIN KINASES

-

Page/Page column 41, (2008/12/05)

The invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them

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