16942-66-8Relevant articles and documents
Promiscuous 2-aminothiazoles (PrATs): A frequent hitting scaffold
Devine, Shane M.,Mulcair, Mark D.,Debono, Cael O.,Leung, Eleanor W. W.,Nissink, J. Willem M.,Lim, San Sui,Chandrashekaran, Indu R.,Vazirani, Mansha,Mohanty, Biswaranjan,Simpson, Jamie S.,Baell, Jonathan B.,Scammells, Peter J.,Norton, Raymond S.,Scanlon, Martin J.
, p. 1205 - 1214 (2015)
We have identified a class of molecules, known as 2-aminothiazoles (2-ATs), as frequent-hitting fragments in biophysical binding assays. This was exemplified by 4-phenylthiazol-2-amine being identified as a hit in 14/14 screens against a diverse range of
Synthesis and antimicrobial activities of some novel 2,3-substituted-1,3-thiazolidin-4-ones derived from 2-amino-1,3-thiazole
Maher
, p. 2794 - 2798 (2017/11/10)
New 2,3-substituted-1,3-thiazolidin-4-one (6a-f) were prepared by cyclocondensation of 2-[6-(4-chlorobenzyloxy)-2-naphthyliden]-4-(4-substituted phenyl)-5-methyl-1,3-thiazole (5a-f) and mercaptoacetic acid in benzene. The synthesized compounds were charac
IMPROVED MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR
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Paragraph 00266, (2013/06/27)
Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Such compounds disrupt Nek2/Hec1 binding and may be useful as chemotherapeutic agents for neoplastic diseases
Modulators Of HEC1 Activity And Methods Therefor
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Page/Page column 9-10, (2011/10/10)
Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Especially preferred compounds disrupt Nek2/Hec1 binding and are therefore useful as chemotherapeutic agent for neoplastic diseases.