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CAS

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179950-77-7

Methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate is a chemical compound with the molecular formula C11H11NO4. It is an ester derivative of 1,4-benzoxazine and is commonly used in the chemical and pharmaceutical industries. It is a white crystalline solid with a molecular weight of 217.21 g/mol and has a melting point of 80-83°C. methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate is often utilized as a building block in the synthesis of various organic compounds and pharmaceutical drugs due to its unique structure and reactivity. Additionally, it has been found to exhibit potential biological activities, making it a valuable tool in drug discovery and development.

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  • methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate

    Cas No: 179950-77-7

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  • 179950-77-7 Structure

  • Basic information

    1. Product Name: methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate
    2. Synonyms: methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate
    3. CAS NO:179950-77-7
    4. Molecular Formula: C11H11NO4
    5. Molecular Weight: 221.20934
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 179950-77-7.mol

  • Chemical Properties

    1. Melting Point: 159-161°
    2. Boiling Point: 407.1±45.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.244±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 12.09±0.40(Predicted)
    10. CAS DataBase Reference: methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate(179950-77-7)
    12. EPA Substance Registry System: methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate(179950-77-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 179950-77-7(Hazardous Substances Data)

179950-77-7 Usage

Uses

Used in Chemical Industry:
Methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate is used as a building block for the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable component in the creation of new chemical entities.
Used in Pharmaceutical Industry:
Methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate is used as a building block in the synthesis of pharmaceutical drugs. Its potential biological activities and unique structure contribute to the development of new therapeutic agents.
Used in Drug Discovery and Development:
Methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate is used as a valuable tool in drug discovery and development. Its potential biological activities and unique structure make it a promising candidate for the creation of new pharmaceutical compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 179950-77-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,9,5 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 179950-77:
(8*1)+(7*7)+(6*9)+(5*9)+(4*5)+(3*0)+(2*7)+(1*7)=197
197 % 10 = 7
So 179950-77-7 is a valid CAS Registry Number.

179950-77-7Downstream Products

179950-77-7Relevant articles and documents

The discovery of potent small molecule activators of human STING

Pryde, David C.,Middya, Sandip,Banerjee, Monali,Shrivastava, Ritesh,Basu, Sourav,Ghosh, Rajib,Yadav, Dharmendra B.,Surya, Arjun

supporting information, (2020/10/09)

The adaptor protein STING plays a major role in innate immune sensing of cytosolic nucleic acids, by triggering a robust interferon response. Despite the importance of this protein as a potential therapeutic target for serious unmet medical conditions inc

SMYD INHIBITORS

-

, (2017/07/18)

The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Benzoxazine and benzothiazine derivatives and their use in pharmaceuticals

-

Example 4, (2010/01/31)

Described are benzoxazine and benzothiazine compounds of the formula I defined herein, methods for their preparation and methods for their use in pharmaceuticals based on their activity as NO-synthases (NOS) inhibitors.

Synthesis and quantitative structure-activity relationships of N-(3- oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl)guanidines as Na/H exchange inhibitors

Yamamoto, Takeshi,Hori, Manabu,Watanabe, Ikuo,Tsutsui, Hisayoshi,Harada, Kengo,Ikeda, Shqji,Maruo, Joji,Morita, Tominori,Ohtaka, Hiroshi

, p. 1716 - 1723 (2007/10/03)

N-(3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl)guanidines 4 were prepared and tested for Na/H exchange inhibitory activities in order to clarify the structure-activity relationship (SAR). Quantitative SAR (QSAR) analysis of 6-carbonylguanidines 4 in

1, 4-benzoxazine derivative and pharmaceutical compositions containing the same

-

, (2008/06/13)

A 1,4-benzoxazine derivative of the following formula (I): STR1 or a pharmaceutically acceptable salt thereof is disclosed. The compound of the present invention is useful as a medicament for preventing or treating disorders induced by intracellular acidosis during myocardial ischemia, such as cardiac dysfunction, myocardial necrosis, arrhythmia, reperfusion injury, and the like, which are observed in ischemic heart diseases (e.g. myocardial infarction, angina pectoris, etc.).

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