180573-13-1Relevant articles and documents
Investigation of 1-bromo-3-buten-2-one as building block in organic synthesis
Westerlund, Andreas,Gras, Jean-Louis,Carlson, Rolf
, p. 5879 - 5883 (2001)
1-Bromo-3-buten-2-one is investigated as a building block for organic synthesis. Reduction to the corresponding alcohol works best with lithium aluminium hydride, reaction with primary amines gives 5-membered-aza-heterocycles in moderate yields and reaction with activated methylene compounds to form 5-membered-carbocycles gave unsatisfactory yields when a one-pot-procedure was used. The first step of a stepwise protocol, a Michael addition, is discussed.
Novel dicarboxylic acid derivatives
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Page/Page column 14, (2008/06/13)
The present patent application concerns new compounds of formula (I): displaying agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as immunosuppressive agents.
β elimination of a phosphonate group from an alkoxyl radical - Intramolecular acylation using acylphosphonate derivatives as carbonyl group acceptors
Cho, Chang Ho,Kim, Sunggak
, p. 917 - 921 (2007/10/03)
The possibility of β elimination of a phosphonate group in radical reactions was studied. The facile β elimination of the phosphonate group from an alkoxyl radical was observed for the first time, whereas the β elimination of the phosphonate group from an
β-elimination of a phosphonate group from an alkoxy radical: An intramolecular acylation approach using an acylphosphonate as a carbonyl group acceptor
Kim, Sunggak,Cho, Chang Ho,Lim, Chae Jo
, p. 9574 - 9575 (2007/10/03)
On the basis of facile β-elimination of a phosphonate group from an alkoxy radical, intramolecular acylation reaction has been developed, in which an acylphosphonate is used as an excellent carbonyl group radical acceptor. Copyright
Improved synthesis of (RS)-3-oxocyclopentanecarboxylic acid: Characterisation of the intermediates
Sung,Bisel,Frahm
, p. 521 - 524 (2007/10/03)
An improved synthesis of the (RS)-3-oxocyclopentanecarboxylic acid (7) in 22% overall yield is described together with the characterisation of the intermediates. The reaction sequence proceeds via Dieckmann cyclisation of ethyl butane-1,2,2,4-tetracarboxylate (1), subsequent acidic hydrolysis and a final decarboxylation. Furthermore, the yet unknown composition of the mixture obtained intermediately from the Dieckmann cyclisation has been elucidated by means of 1H and 13C NMR-spectroscopy.
Radical reaction of S-phenyl chlorothioformate with alkyl iodides: Free radical-mediated carboxylation approach
Kim, Sunggak,Jon, Sang Yong
, p. 815 - 816 (2007/10/03)
Free radical-mediated carboxylation is achieved by treatment of alkyl iodides with S-phenyl chlorothioformate and bis(tributyltin) with irradiation at 300 nm.
Radical cyclization of thio- and seleno-esters - An intramolecular acylation approach
Kim, Sunggak,Jon, Sang Yong
, p. 1335 - 1336 (2007/10/03)
Both thio- and seleno-esters are utilized as carbonyl equivalent radical acceptors in radical cyclizations, where selenoesters are more efficient than thioesters due to the better leaving ability of the phenylseleno group.
