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Acid-PEG3-t-butyl ester is a PEGylated molecule featuring a t-butyl protected carboxyl group and a terminal carboxylic acid, which can be activated to form stable amide bonds with primary amine groups. The hydrophilic PEG spacer enhances its solubility in aqueous environments, and the t-butyl group can be removed under acidic conditions to reveal the free carboxyl group.

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  • 1807539-06-5 Structure
  • Basic information

    1. Product Name: Acid-PEG3-t-butyl ester
    2. Synonyms: Acid-PEG3-t-butyl ester;COOH-PEG3-OtBu
    3. CAS NO:1807539-06-5
    4. Molecular Formula: C14H26O7
    5. Molecular Weight: 306.35204
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1807539-06-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 423.2±35.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.106±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: Soluble in Water, DMSO, DCM, DMF
    9. PKA: 4.28±0.10(Predicted)
    10. CAS DataBase Reference: Acid-PEG3-t-butyl ester(CAS DataBase Reference)
    11. NIST Chemistry Reference: Acid-PEG3-t-butyl ester(1807539-06-5)
    12. EPA Substance Registry System: Acid-PEG3-t-butyl ester(1807539-06-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1807539-06-5(Hazardous Substances Data)

1807539-06-5 Usage

Uses

Used in Pharmaceutical Industry:
Acid-PEG3-t-butyl ester is used as a PEGylation agent for improving the solubility, stability, and bioavailability of therapeutic agents. The terminal carboxylic acid allows for covalent attachment to primary amine-containing drugs, while the PEG spacer reduces immunogenicity and proteolytic degradation, leading to enhanced pharmacokinetic properties.
Used in Bioconjugation:
Acid-PEG3-t-butyl ester is used as a bioconjugation reagent for the site-specific attachment of biomolecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The t-butyl protected carboxyl group allows for selective deprotection and subsequent coupling under mild conditions, enabling the formation of well-defined bioconjugates with controlled structure and function.
Used in Drug Delivery Systems:
Acid-PEG3-t-butyl ester is used as a component in the design of drug delivery systems, such as nanoparticles, liposomes, or hydrogels, for the encapsulation and controlled release of therapeutic agents. The PEG spacer provides steric stabilization and reduces non-specific interactions, while the terminal carboxylic acid allows for the attachment of drugs or targeting moieties, enabling the development of stimuli-responsive and targeted drug delivery platforms.

Check Digit Verification of cas no

The CAS Registry Mumber 1807539-06-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,7,5,3 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1807539-06:
(9*1)+(8*8)+(7*0)+(6*7)+(5*5)+(4*3)+(3*9)+(2*0)+(1*6)=185
185 % 10 = 5
So 1807539-06-5 is a valid CAS Registry Number.

1807539-06-5Upstream product

1807539-06-5Downstream Products

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