185989-39-3Relevant articles and documents
A synthetic receptor for asymmetric dimethyl arginine
James, Lindsey I.,Beaver, Joshua E.,Rice, Natalie W.,Waters, Marcey L.
, p. 6450 - 6455 (2013)
Dynamic combinatorial chemistry was utilized to identify a novel small molecule receptor, A2D, for asymmetric dimethyl arginine (aRMe 2), which is a post-translational modification (PTM) in proteins. It is known to play a role in a number of diseases, including spinal muscular atrophy, leukemia, lymphoma, and breast cancer. The receptor exhibits 2.5-7.5-fold selectivity over the isomeric symmetric dimethyl arginine, depending on the surrounding sequence, with binding affinities in the low micromolar range. The affinity and selectivity of A2D for the different methylated states of Arg parallels that of proteins that bind to these PTMs. Characterization of the receptor-PTM complex indicates that cation-π interactions provide the main driving force for binding, loosely mimicking the binding mode found in the recognition of dimethyl arginine by native protein receptors.
Bicyclic-Fused Heteroaryl or Aryl Compounds
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Paragraph 0413, (2015/10/28)
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Enantioselective total synthesis of (S)-bisoranjidiol, an axially chiral bisanthraquinone
Podlesny, Erin E.,Kozlowski, Marisa C.
supporting information; experimental part, p. 1408 - 1411 (2012/06/01)
The first enantioselective total synthesis of the bisanthraquinone (S)-bisoranjidiol and an unnatural regioisomer has been accomplished. Key features of the synthesis include the asymmetric oxidative biaryl coupling of a hindered 8-substituted 2-naphthol,
Oxofunctionalized trans-2-carboxycinnamic acids by catalytic domino oxidation of naphthols and hydronaphthoquinones
Giurg, Miroslaw,Muchalski, Hubert,Kowal, Ewa
experimental part, p. 2526 - 2539 (2012/08/07)
(Chemical Equation Presented) The catalytic oxidation of naphthalenes was investigated. Hydrogen peroxide (30% aqueous) was used as an oxygen source, and 2,2′-dinitro-4,4′-ditrifluoromethyldiphenyl diselenide was the oxygen-transfer catalyst. Unsubstitute
Bicyclic compositions and methods for modulating a kinase cascade
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Page/Page column 133-135, (2008/06/13)
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
Kinase inhibitors
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Page/Page column 20-21, (2010/11/08)
The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitors are provided. The protein kinases produced usi
Photochromic compounds
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Page 50, (2008/06/13)
Various non-limiting embodiments disclosed herein relate generally to photochromic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. Other non-limiting embodiments relate to photochromic-dichroic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. For example, one non-limiting embodiment provides a thermally reversible, photochromic compound adapted to have at least a first state and a second state, wherein the thermally reversible, photochromic compound has an average absorption ratio greater than 2.3 in at least one state as determined according to CELL METHOD. Another non-limiting embodiment provides a photochromic compound comprising: (a) at least one photochromic group chosen from a pyran, an oxazine, and a fulgide; and (b) at least one lengthening agent L attached to the at least one photochromic group and represented by the formula —[S1]c-[Q1-[S2]d]d′-[Q2-[S3]e]e′-[Q3-[S4]f]f′—S5—P, which is described herein.
Signal transduction inhibitors, compositions containing them
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, (2008/06/13)
This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to p
The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 1: Hydroxynaphthalene derivatives
Marsilje, Thomas H.,Milkiewicz, Karen L.,Hangauer, David G.
, p. 477 - 481 (2007/10/03)
A series of hydroxynaphthalene pp60(c-src) non-peptide inhibitors was designed, using the crystal structure of the insulin receptor tyrosine kinase as a qualitative model, to target the peptide substrate binding site. Representative inhibitors were shown to bind non-competitively with respect to ATP. (C) 2000 Elsevier Science Ltd. All rights reserved.
