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CAS

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186097-54-1

DK-AH 269 is a compound that has been utilized in various scientific and medical research applications. It is known for its ability to act as a hyperpolarization-activated and cyclic nucleotide-gated channel (HCN) antagonist, which allows for the study of its effects on specific cellular processes and functions.

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  • 186097-54-1 Structure

  • Basic information

    1. Product Name: DK-AH 269
    2. Synonyms: Cilobradine hydrochloride, (S)-(+)-7,8-Dimethoxy-3-[[1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride;Cilobradine DK-AH;(S)-(+)-7,8-Dimethoxy-3-[[1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride;Cilobradine (hydrochloride)
    3. CAS NO:186097-54-1
    4. Molecular Formula: C28H38N2O5.ClH
    5. Molecular Weight: 519.078
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 186097-54-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 655.7°C at 760 mmHg
    3. Flash Point: 350.4°C
    4. Appearance: white/solid
    5. Density: N/A
    6. Vapor Pressure: 1.96E-17mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: 2-8°C
    9. Solubility: H2O: ~20 mg/mL
    10. CAS DataBase Reference: DK-AH 269(CAS DataBase Reference)
    11. NIST Chemistry Reference: DK-AH 269(186097-54-1)
    12. EPA Substance Registry System: DK-AH 269(186097-54-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 186097-54-1(Hazardous Substances Data)

186097-54-1 Usage

Uses

Used in Neuroscience Research:
DK-AH 269 is used as an HCN channel antagonist for studying its effects on the inhibition of Ih in HCN-deficient hair cells of mice. This application helps researchers understand the role of HCN channels in auditory processing and the potential therapeutic applications of DK-AH 269 in treating hearing-related disorders.
Used in Circadian Rhythm Studies:
DK-AH 269 is used as an HCN blocker to study its effects on action potential firing in the suprachiasmatic nucleus (SCN) neurons. The SCN is a critical brain region responsible for regulating circadian rhythms, and understanding the impact of DK-AH 269 on these neurons can provide insights into the development of treatments for sleep disorders and other conditions related to the circadian system.

Biochem/physiol Actions

DK-AH 269 is a bradycardiac agent.

Check Digit Verification of cas no

The CAS Registry Mumber 186097-54-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,0,9 and 7 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 186097-54:
(8*1)+(7*8)+(6*6)+(5*0)+(4*9)+(3*7)+(2*5)+(1*4)=171
171 % 10 = 1
So 186097-54-1 is a valid CAS Registry Number.
InChI:InChI=1/C28H38N2O5.ClH/c1-32-24-8-7-20(14-25(24)33-2)9-12-29-11-5-6-21(18-29)19-30-13-10-22-15-26(34-3)27(35-4)16-23(22)17-28(30)31;/h7-8,14-16,21H,5-6,9-13,17-19H2,1-4H3;1H/t21-;/m0./s1

186097-54-1 Well-known Company Product Price

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  • Sigma

  • (D6942)  DK-AH 269  ≥98% (HPLC), solid

  • 186097-54-1

  • D6942-5MG

  • 1,711.71CNY

  • Detail

  • Sigma

  • (D6942)  DK-AH 269  ≥98% (HPLC), solid

  • 186097-54-1

  • D6942-25MG

  • 6,809.40CNY

  • Detail

186097-54-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Cilobradine hydrochloride

1.2 Other means of identification

Product number -
Other names DK-AH 269

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:186097-54-1 SDS

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