191327-28-3 Usage
Uses
Used in Pharmaceutical Industry:
(R)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER is used as a pharmaceutical compound for its analgesic, anti-inflammatory, and neuroprotective properties. It is being studied for its potential use in the treatment of Parkinson's disease and other neurological disorders.
Used in Chemical Synthesis:
(R)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER is used as a building block in the synthesis of other pharmaceutical compounds, contributing to the development of new drugs with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 191327-28-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,3,2 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 191327-28:
(8*1)+(7*9)+(6*1)+(5*3)+(4*2)+(3*7)+(2*2)+(1*8)=133
133 % 10 = 3
So 191327-28-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO2/c1-14-11(13)10-6-8-4-2-3-5-9(8)7-12-10/h2-5,10,12H,6-7H2,1H3
191327-28-3Relevant articles and documents
Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective σ1 ligands. Part 1
Charton, Julie,Gassiot, Amaury Cazenave,Girault-Mizzi, Sophie,Debreu-Fontaine, Marie-Ange,Melnyk, Patricia,Sergheraert, Christian
, p. 4833 - 4837 (2007/10/03)
Herein is described a new class of selective σ1 ligands consisting of tetrahydroisoquinoline-hydantoin (Tic-hydantoin) derivatives. Compound 3a has high affinity (IC50 = 16 nM) for the σ1 receptor and is selective in a large panel of therapeutic targets. This first study presents structural changes around the Tic-hydantoin core, leading to a Tic-hydantoin analogue with a higher σ1 affinity (IC50 ≈ 1 nM).
