196192-08-2Relevant articles and documents
Simplified procedure for general synthesis of monosubstituted piperazines-from a batch reaction vessel to a flow (microwave) reactor
?ev?ík, Richard,?imbera, Jan,Havránková, Eva,Něme?ková, Dana,Pazdera, Pavel
, (2020/05/25)
We reported a novel simplified synthetic procedure for the preparation of monosubstituted piperazine derivatives which can now be easily prepared in a one-pot-one-step way from a protonated piperazine with no need of introduction of a protecting group. Reactions, proceeding either at room or higher temperatures in common solvents, involve heterogeneous catalysis by metal ions supported on commercial polymeric resins. A general synthetic scheme was successfully applied to afford a wide range of monosubstituted piperazines. Furthermore, we picked up a set of piperazine derivatives and studied the possibilities of microwave acceleration of given synthetic reactions to make them even more efficient. Our research proceeded from a simple batch technique to the construction of a flow microwave reactor prototype and resulted in promising findings which are summarized and discussed in the article.
5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
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Paragraph 0760, (2015/12/05)
Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
NOVEL CONJUGATES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
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, (2012/09/11)
Provided herein are cryptophycin conjugates and compositions containing them. Methods of making and using such compounds also are provided
NOVEL ADENINE COMPOUND
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Page/Page column 53, (2008/12/06)
An adenine compound or its pharmaceutically acceptable salt as a medicament as shown following formula (1): wherein R1 is optionally substituted alkyl group, etc., X is oxygen atom, etc., A is 4 to 8 membered optionally substituted saturated or unsaturated heterocyclic group containing 1 to 2 hetero atoms selected from 1 to 3 nitrogen atoms, 0 to 1 oxygen atom and 0 to 1 sulfur atom, L1 and L2 are independently straight or branched chain alkylene, or a single bond, R2 is optionally substituted alkyl group, etc.
