142-64-3 Usage
Uses
Different sources of media describe the Uses of 142-64-3 differently. You can refer to the following data:
1. It is used as a one day wormer, either in water or feed, for the control of Round worms in poultry, swine, and horses. It also controls nodular worms in swine, and small strongyles in horses.
2. In the manufacture of fibers, pharmarceuticals, and insecticides.
3. Piperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.
General Description
White to cream-colored needles or powder. Mp: 318-20°C (with decomposition).
Reactivity Profile
PIPERAZINE DIHYDROCHLORIDE is incompatible with the following: Water, HEAT, flames, oxidizers. PIPERAZINE DIHYDROCHLORIDE absorbs moisture from air. PIPERAZINE DIHYDROCHLORIDE may create flammable condition upon contact with HEAT, FLAMES and OXIDIZERS.
Safety Profile
Moderately toxic by
intraperitoneal route. Mildly toxic by
ingestion. When heated to decomposition it
emits very toxic fumes of NOx and HCl.
Used in making fiber, pharmaceuticals, and
insecticides. See also PIPERAZINE.
Potential Exposure
Agricultural chemical, Suspected reprotoxic hazard. Piperazine is used to manufacture anthelmintics, antifilarials, antihistamines, and tranquilizers; the dihydrochloride is used in the manufacture of fibers, pharmaceuticals and insecticides. They are used as an intermediate in the manufacture of, pesticides, rubber chemicals and fibers. Also, piperazine is widely available, effective, and safe when used on an occasional basis against ascaride infections. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworn, it has been withdrawn from use on the grounds that other effective drugs are now available. Clinical dosages occasionally induce transient neurological signs and, in some circumstances, the drug may generate small amounts of nitrosamine in the stomach, which at considerably greater dosage in experimental animals has been demonstrated to have a carcinogenic potential.
Carcinogenicity
Piperazine dihydrochloride is an
irritant and sensitizer.
Little information exists on the toxicology
of piperazine dihydrochloride in humans or in
animals. Acute human exposures to the dust
have reportedly resulted in irritation to the
eyes, mild to moderate skin burns, and sensitization. Exposure levels and duration were not
available.
Purification Methods
Crystallise the salt from aqueous EtOH and dry it at 110o. [Beilstein 23 III/IV 17, 23/1 V 30.]
Incompatibilities
Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.
Check Digit Verification of cas no
The CAS Registry Mumber 142-64-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 2 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 142-64:
(5*1)+(4*4)+(3*2)+(2*6)+(1*4)=43
43 % 10 = 3
So 142-64-3 is a valid CAS Registry Number.
InChI:InChI=1/2C2H8N2.2ClH/c2*3-1-2-4;;/h2*1-4H2;2*1H
142-64-3Relevant articles and documents
Catalytic one-pot three-component synthesis of 3,3′-disubstituted oxindoles and spirooxindole pyrans by mixed ligand transition metal complexes
Hegade, Sujit,Gaikwad, Gautam,Jadhav, Yuvraj,Pore, Avinash,Mulik, Abhijeet
, p. 95 - 103 (2021/11/22)
Abstract: New three-component reaction was developed via one-pot strategy for the synthesis of functionalized 3,3′-disubstituted oxindoles and spirooxindole through the reaction among isatin, malononitrile, and acetone/indole/nitromethane/acetylacetone/di
A synthesis method according to sets up qu tan hydrobromide
-
Paragraph 0053-0054, (2017/10/22)
The invention discloses a synthesis method of eletriptan hydrobromate, which comprises the following steps: reacting (R)-1-acetyl-3-(N-methylpyrrolidinyl-2-methy)-5-bromo-1H-indole and metal in an organic solvent to form a metal complex, reacting the metal complex with a boron reagent in an organic solvent to form aryl borane or aryl borate, carrying out acid-catalyzed hydrolysis to obtain aryl boric acid, and carrying out coupling and hydrolysis on the aryl boric acid and 2-chloroethylphenyl sulfone under the actions of a catalyst and an alkali to obtain eletriptan, or directly carrying out coupling and hydrolysis on the metal complex and 2-chloroethylphenyl sulfone to obtain eletriptan; and carrying out salification on the eletriptan and hydrobromic acid in an organic solvent to finally obtain the eletriptan hydrobromate. The method is simple to operate, has the advantages of high safety, high stability, low cost and higher yield, and is suitable for industrial production.
A N, 6 diphenyl pyrimidine -4 - amine Bcr - Abl inhibitor and its preparation method and application (by machine translation)
-
Paragraph 0041; 0049-0050; 0066; 0100, (2017/04/28)
The invention discloses a N, 6 diphenyl pyrimidine - 4 - amine Bcr - Abl inhibitor and its preparation method and application, the structural formula of the inhibitor for the wherein R is a single substituent or double-substituent, substituent is alkyl or halogen; R1 As a single substituent or double-substituent, substituent is alkyl or halogen. The series of inhibitors in vitro ABL1 kinase restraining effects, and can inhibit the proliferation of tumor cells, can be used for anti-tumor pharmaceutical preparation, in particular CML (chronic granulocytic leukemia) drug. The invention provides N, 6 diphenyl pyrimidine - 4 - amine Bcr - Abl inhibitor preparation method, raw materials are apt, mild reaction conditions, the reaction process is simple in operation, reagent used and cheap. (by machine translation)
